Title

Lipid and renal profile in assessing the severity of alcoholic liver disease

Authors

G. Chitrasivasankari¹, V. Gomathi^1,*, R. Nachiappan¹, Kaarthikeyan Gurumoorthy² & S. Mahalakshmi³

Affiliation

¹Institute of Biochemistry, Madras Medical College, RGGGH, Chennai, India; ²Saveetha Dental College& Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai – 77, India; ³Department  of Biochemistry, Madurai Medical College, Madurai. *Corresponding author

Email

G. Chitrasivasankari - E-mail: drmcvk7896@gmail.com

V. Gomathi – E-mail: gomathivdr@gmail.com; Phone: +91 9600081279

R. Nachiappan - E-mail: nachidevi@yahoo.co.in

Gurumoorthy Kaarthikeyan - E-mail:kaarthikeyang78@gmail.com

S. Mahalakshmi - Email: drmahakvlgh@gmail.com

Article Type

Research Article

Date

Received September 2, 2022; Revised October 3, 2022; Accepted October 6, 2022, Published October 31, 2022

Lipid and Renal dysfunction in Alcoholic liver disease (ALD) patients occurs either due to multi-organ involvement or secondary to alcoholism. This study was conducted to evaluate the role of lipid and renal parameters in assessing the severity of progression of ALD. Sixty cases of ALD (two groups based on compensated and decompensated features) and thirty healthy controls for comparison were included. Lipid profile (Total Cholesterol, LDL, HDL and Triglycerides) and renal parameters (serum urea, creatinine and uric acid), total and direct bilirubin, total protein and albumin were measured using automated chemistry analyzer. There was a significant decrease in Total cholesterol ,LDL and HDL levels and  increased triglycerides when compared to  controls (mean of 128.4 ± 59 vs 155 ± 27.2, 77 ± 44.3  vs 97.4 ± 27.2, 28.3 ± 18 vs 39.5 ± 14.1 and 115.8 ± 70.4 vs 91 ± 38 mg/dL respectively). Lipid profile showed a linear decrease while progressing from compensated to decompensated ALD. Renal parameters revealed a statistically significant decrease in serum urea ,increased  creatinine and uric acid levels when compared to controls (17.57±2.96 vs23.73±4.94, 1.12±0.55 vs0.88±0.16,6.60±1.32 vs 4.68±1.40 mg/dL respectively).Total cholesterol and HDL showed a linear decrease when ALD progresses. Serum uric acid showed an early increase in compensated stage of ALD. This study inferred that Total cholesterol, TGL, HDL and uric acid can be used for assessing the severity of progression of ALD.

Keywords

Alcoholic liver disease, lipid profile, hepato-renal syndrome, health.

Citation

     Chitrasivasankari et al. Bioinformation 18(10): 1036-1040 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.