Title
Evaluation of serum proteome from Indian psoriasis patients
Authors
Saiqa R. Shah1, Varshasnata Mohanty2, Debajit Chaudhury3, T.S. Keshava Prasad4, Manjunath Mala Shenoy1,*
Affiliation
1Yenepoya Medical College, Yenepoya (Deemed to be university), Deralakatte, Mangalore, India; 2Institute of Life sciences, Bhubaneswar, Odisha, India; 3Stem Cell and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University) India; 4Centre for Systems Biology and Molecular Medicine Yenepoya Research Center, Yenepoya (Deemed to be University) India; *Corresponding author
Saiqa R. Shah - E-mail: shah.saiqa2@gmail.com
Varshasnata Mohanty - E-mail: varshasnata.mohanty@gmail.com
Debajit Chaudhary - E-mail: chaudhurydebajit@gmail.com
TS Keshava Prasad - E-mail: keshav@yenepoya.edu.in
Manjunath Shenoy - E-mail:manjunath576117@yahoo.co.in
Article Type
Research Article
Date
Received December 28, 2021; Revised March 2, 2022; Accepted March 31, 2022, Published March 31, 2022
Abstract
Psoriasis is a polygenic chronic skin condition, associated with many systemic disorders. Though it is most studied dermatological condition, molecular mechanism leading to its pathogenesis is still unclear. An insight into its proteome may help unrevealing some biomarkers and therapeutic targets. In this study, we carried out mass spectrometry based quantitative proteomic analysis of serum from psoriasis patients by employing Tandem Mass Tags (TMT) approach. We identified 861,887 MS/MS spectra corresponding to 493 proteins. These dysregulated proteins were further classified by Gene Ontology and protein-protein interaction of dys-regulated proteins revealed networks in psoriasis patients.
Keywords
Psoriasis, LC-MS/MS, Orbitrap, biomarkers, serum
Citation
Shah et al. Bioinformation 18(3): 141-146 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
