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MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) in adolescents at West Bengal, India


Sayan Chattopadhyay1, Rachita Arora1, Amit Kishor2, Shivani Singh3, Abhijeet Alok4 & Mainak Mitra1



1Burdwan Dental College and Hospital, West Bengal, India; 2Primary Health Centre Baniyapur, Chapra, Bihar, India; 3Dr B R Ambedkar Institute of Dental Sciences and Hospital, Patna, Bihar, India; 4Primary Health Centre, Khaira, Jamui, Bihar, India; *Corresponding author



Sayan Chattopadhyay- E-mail:drsayan23@gmail.com

Rachita Arora- E-mail: rachita.arora1@gmail.com

Amit Kishore- E-mail: dramitkishor1@gmail.com

Shivani Singh- E-mail: drshivani37@gmail.com

Abhijeet Alok- E-mail: drabhijeetalok786@gmail.com

Mainak Mitra- E-mail: mmitra65@gmail.com


Article Type

Research Article



Received January 3, 2022; Revised March 3, 2022; Accepted March 31, 2022, Published March 31, 2022



Mucin 4 (MUC4) and matrix metalloproteinase 7 (MMP7) have been reported to be associated with chronic periodontitis as seen in gingival tissue biopsies. Therefore, it is of interest to estimate the levels of MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) samples of periodontitis in adolescents patients at West Bengal, India. MUC4 levels were significantly lower in saliva and GCF from periodontitis patients compared to healthy controls. However, MMP7 levels were found to be significantly higher in saliva and GCF from periodontitis patients. Thus, MUC4 and MMP7 are biomarkers for periodontitis diagnosis and towards further consideration.



Gingival Crevicular Fluid (GCF), matrix metalloproteinase 7(MMP7), mucin 4(MUC4), periodontitis, saliva



Chattopadhyay et al. Bioinformation 18(3): 165-169 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.