Title

Functional assignment to hypothetical proteins in Orientia tsutsugamushi strain Ikeda

Authors

Dixit Sharma^1,*, Sunil Kumar¹, Ankita Sharma², Rakesh Kumar¹, Ranjit Kumar¹, Mahesh Kulharia² & Manish Kumar³

Affiliation

¹Department of Animal Sciences, School of Life Sciences, Central University of Himachal Pradesh, District Kangra, Himachal Pradesh, India - 176206; ²Centre for Computational Biology and Bioinformatics, School of Life Sciences, Central University of Himachal Pradesh, District Kangra, Himachal Pradesh, India - 176206; ³Department of Chemistry and Chemical Sciences, School of Physical and Material Science, Central University of Himachal Pradesh, District Kangra, Himachal Pradesh, India - 176206; *Corresponding author

Email

Dixit Sharma - E-mail: sharmadixit17@hpcu.ac.in; sharmadixit17@gmail.com

Sunil Kumar - E-mail: sunilibes@hpcu.ac.in

Ankita Sharma - E-mail: sharma889ankita@gmail.com

Rakesh Kumar - E-mail: drthakurcuhp@hpcu.ac.in

Ranjit Kumar - E-mail: ranjitcuhp@hpcu.ac.in

Mahesh Kulharia - E-mail: kulharia@hpcu.ac.in

Manish Kumar - E-mail: manishssu26@hpcu.ac.in

Article Type

Research Article

Date

Received October 21, 2021; Revised March 11, 2022; Accepted March 31, 2022, Published March 31, 2022

Orientia tsutsugamushi (O. tsutsugamushi) is an intracellular bacterial pathogen which causes zoonosis scrub typhus in humans. Genome of O. Tsutsugamushi strain Ikeda contains 214 hypothetical proteins (HPs) which is nearly 20% of the total proteins. Domain and family based functional analysis of HPs results in the annotation of 44 hypothetical proteins. The annotated HPs were classified in to five main classes namely, gene expression and regulation, transport, metabolism, cell signaling and proteolysis. Thus, computational analysis of HPs helps to understand their putative roles in various biological and cellular processes, including pathogenesis for further consideration as potential therapeutic targets.

Keywords

Orientia tsutsugamushi, hypothetical proteins, therapeutic targets

Citation

Sharma et al. Bioinformation 18(3): 188-195 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.