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Title

FASTK family of genes linked to cancer

Authors

Abilasha Ramasubramanian1,*, A Paramasivam2, & Pratibha Ramani1

 

Affiliation

1Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Poonamallee High Road, Chennai, Tamilnadu - 600077, India; 2Department of Dental Research Cell- Blue Lab, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Poonamallee High Road, Chennai, Tamilnadu - 600077, India; *Corresponding author Abilasha Ramasubramanian - Phone no: +919600191071

 

Email

Abilasha Ramasubramanian - E-mail: abilasha@saveetha.com

Paramasivam A - E-mail: paramasivama.sdc@saveetha.com

Pratibha Ramani - E-mail: pratibaramani@saveetha.com

 

Article Type

Research Article

 

Date

Received February 2, 2022; Revised March 25, 2022; Accepted March 31, 2022, Published March 31, 2022

 

Abstract

Fas Activated Serine/Threonine Kinase (FASTK) family is a protein family encoded in the nuclear genome that spans the mitochondria and executes numerous functions, and consists of FASTK, the founding member along with 5 homologous proteins FASTKD1-5. Up regulation of FASTK family members have not only been implicated in tumour progression and invasion but also in increased resistance to chemotherapy proven by their knockdown leading to increased sensitivity to drugs. Thus, this review reports the implication of FASTK proteins in cancer and hence provides a scope to emphasise the role of these proteins in Oral Cancer.

 

Keywords

FAST, FASTK family, cancer, mitochondrial dysfunction

 

Citation

Ramasubramanian et al. Bioinformation 18(3): 206-213 (2022)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.