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Gene polymorphism among hypertensive patients with coronary artery disease


D. Selvakumar 1, C.K. Vijayasamundeeswari 1,*, E. Gnanadesigan2 & N. Sivasubramanian3



1Department of Biochemistry, Vinayaka Mission’s Kirupananda Variyar Medical college and Hospitals , Salem, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem -636 308, Tamilnadu, India; 2Department of Physiology, Norton Medical College & Research Centre, Sankalchand Patel University, Visnagar - 384315, Gujarat, India; 3Department of Psychiatric Nursing, Nootan College of Nursing, Sankalchand Patel University, Visnagar- 384315, Gujarat, India; *Corresponding author



D. Selvakumar - E-mail: selvarajmscbio@gmail.com

C.K. Vijayasamundeeswari - E-mail: biochemistrysalem@gmail.com

E. Gnanadesigan - E-mail: edesigan_phy@nootanmedical.edu.in

N. Sivasubramanian - E-mail: Sn.fn@spu.ac.in


Article Type

Research Article



Received January 12, 2022; Revised March 31, 2022; Accepted March 31, 2022, Published March 31, 2022



The obstruction of the coronary arteries causes Coronary Artery Disease (CAD). It has been reported that interleukin-6 gene is related to the development of cardiovascular diseases such as atherosclerosis and coronary artery disease. This was due to the large variability and short half-life of interleukin 6 (IL-6). There are few studies on the link between interleukin 6 and CAD on the patients with hypertension. Therefore, goal of this study was to see if there is a link between IL-6 gene polymorphisms and coronary artery disease with hypertension patients. The polymorphisms were carried out by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The data was determined for statistical significance using chi-square analysis. A significant difference was found in the GG genotype of IL-6 -174, which was more frequent in cases of CAD (48.67 %) than in controls (8%) and 95% CI was 0.473455 - 0.500326; P<0.010620511. The GG genotype of IL-6-572C/G polymorphism was more frequent in cases of CAD (42.6%) compared with controls (8%) and 95% CI 0.386724 - 0.480945; P<0.017939631). likewise, significant association of variant allele G with CAD patients was reported. Hypertension was significantly higher among patients as compared to controls (P<0.022847535). Our findings indicated that both gene polymorphisms may be associated with development of CAD.



IL-6 -174, IL-6-572, CAD, hypertension, gene polymorphism



Selvakumar et al. Bioinformation 18(3): 239-244 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.