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Molecular docking analysis of metformin analogues with GSK-3β


Ponnu lakshmi Rajagopal1, Vidhya Rekha Umapathy2, Sandhya P3, Fathima JH4, Ramajayam Govindan5, Chella Perumal Palanisamy6, Vishnu Priya Veeraraghavan7 & Selvaraj Jayaraman7,*



1Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, India; 2Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; 3Department of Biochemistry, Allied Health science, Dr. M.G.R Educational and Research Institute, Chennai India; 4Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India; 5Multi Disciplinary Research Unit, Madurai Medical College, Tamilnadu, India; 6State Key Laboratory of Bio-based Materials and Green Papermaking, College of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China; 7Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; *Corresponding author



Ponnulakshmi Rajagopal- E-mail: ramgslaks@gmail.com

Vidhya Rekha Umapathy- E-mail: drvidhyarekha@gmail.com

Sandhya P- E-mail: jselvaendo@gmiail.com

Fathima JH- E-mail: shaziafathimarizwan@gmail.com

Ramajayam Govindan- E-mail: endoibmsramajayam@gmail.com

ChellaPerumal Palanisamy- E-mail: perumalbioinfo@gmail.com

VishnuPriya Veeraraghavan- E-mail: drvishnupriayav@gmail.com

Selvaraj Jayaraman– E-mail: selvarajj.sdc@saveetha.com


Article Type

Research Article



Received January 21, 2022; Revised March 21, 2022; Accepted March 31, 2022, Published March 31, 2022



We report the molecular docking analysis of four analogues of metformin [1-Carbamimidoyl-1,2-dimethylguanidine hydrochloride, Metformin hydrochloride, N1,N1-Dimethyl-N5-methylbiguanide hydrochloride, and N1,N1,N5,N5-Tetrakis(methyl-biguanide hydrochloride] with GSK3.



Diabetes mellitus; GSK-3β; Metformin analogues; Molecular docking studies



Rajagopal et al. Bioinformation 18(3): 269-272 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.