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In vitro antioxidant and anti-diabetic analysis of Andrographis echioides and Andrographis paniculata ethanol extract


Chevuru Sai Shreya Reddy, Gayatri Devi Ramalingam*, J Selvaraj & Jothi Priya



Saveetha Dental College, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, India; *Corresponding Author



Chevuru Sai Shreya Reddy - E-mail: shreyachevuru@gmail.com

R Gayatri Devi - E-mail: gayatridevi@saveetha.com

J Selvaraj - E-mail: selvarajj.sdc@saveetha.com

A Jothi Priya - E-mail: jothipriya.sdc@saveetha.com


Article Type

Research Article



Received March 3, 2022; Revised April 30, 2022; Accepted April 30, 2022, Published April 30, 2022



It is of interest to analyse and compare the antioxidant and anti-diabetic activity of ethanolic extracts of Andrographis echioides and Andrographis paniculata. Andrographis echioides and Andrographis paniculata were collected from a local farm. In vitro antioxidant activity was assessed by the potential of Piperine, Lupeol, beta sitosterol; DPPH free radical scavenging assay was performed by Liyana Pathirana and Shahidi method. In vitro anti-diabetic activity was assessed by alpha amylase inhibitory activity and alpha glucosidase inhibitory activity. The data were analysed by one-way-ANOVA to check the statistical significance among the groups and considered at the levels of p<0.05. Both the ethanolic extracts of Andrographis echioides and Andrographis paniculata showed significant antioxidant and anti-diabetic potential in a dose-dependent manner (100-500μg) and can be used as potential antidiabetic agents. Similar to antioxidant potential, Andrographis paniculata exhibited an increased anti-diabetic potential compared to Andrographis echioides. Data shows that the ethanolic extracts of Andrographis echioides and Andrographis paniculata possessed antioxidant and anti-diabetic activity and hence our present findings conclude that both plants can be considered for the development of natural drugs for the management of diabetes.



Diabetes, antioxidant, Andrographis echioides and Andrographis paniculata, Innovative techniques



Shreya Reddy et al. Bioinformation 18(4): 337-342 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.