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A review on hypo-cholesterolemic activity of Nigella sativa seeds and its extracts


Karmegam Uma Maheswari1,2,*, K. Dilara1, S. Vadivel2, Priscilla Johnson1 & Selvaraj Jayaraman3



1Department of Physiology, Sri Ramachandra Medical College and Research Institute (SRMC & RI), Porur, Chennai- 600116, India; 2Department of Physiology, Karpaga Vinayaga Institute of Medical Education and Research, Madhuranthagam, Chengalpet-603308, Tamil Nadu, India; 3Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Chennai 600077, India; *Corresponding author



K. Uma Maheswari - E-mail: umakarmegam@gmail.com

K. Dilara - E-mail: dilarak@sriramachandra.edu.in

S. Vadivel - E-mail: drsvadivel2012@gmail.com

Priscilla Johnson - E-mail: priscillajohnson@sriramachandra.edu.in

Selvaraj Jayaraman - E-mail: selvarajj.sdc@saveetha.com


Article Type

Research Article



Received March 1, 2022; Revised April 30, 2022; Accepted April 30, 2022, Published April 30, 2022



Nigella sativa (N. sativa) (Family Ranunculaceae) is a popular therapeutic herb in many parts of the world. It is widely used in traditional medical systems such as Unani, Ayurveda and Siddha. Seeds and oil have a long history of folkloric use in many medicinal and culinary systems. The seeds of N. sativa have long been used to treat a variety of illnesses and disorders. Studies on N. sativa and its therapeutic potential have been investigated. This includes anti-diabetic, anticancer, immune-modulatory, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective, renal protective, gastro-protective, antioxidant properties, and several others. Nigella sativa contains thymoquinone. This is a bioactive component of the essential oil with medicinal benefits. Therefore, it is of interest to report a comprehensive data on the therapeutic usefulness of N. sativa in hypo-cholesterolemic activity.



Nigella sativa, black seed, hypo cholesterolemic activity



Uma Maheswari et al. Bioinformation 18(4): 343-348 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.