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Title

Genome sequence analysis of nsp15 from SARS-CoV-2

Authors

Niti Yashvardhini1,*, Deepak Kumar Jha2, Amit Kumar3, Manjush Gaurav3 & Kumar Sayrav4

 

Affiliation

1Department of Microbiology, Patna Women’s College, Patna, 800 001, Bihar, India; 2Department of Zoology, S.M.P. Girls Degree College, Ballia, 277401, Uttar Pradesh, India; 3Department of Botany, Patna University, Patna-800 005, Bihar, India; 4Department of Chemistry, V.K.S. University, Ara-802301, Bihar India; *Corresponding author

 

Email

nitiyashvardhini@gmail.com

 

Article Type

Research Article

 

Date

Received March 1, 2022; Revised April 30, 2022; Accepted April 30, 2022, Published April 30, 2022

 

Abstract

SARS-CoV-2 (Severe Acute Respiratory Syndrome), a causative agent of COVID-19 disease created a pandemic situation worldwide. Nsp15 is a uridine specific endoribonuclease encoded by the genome of SARS-CoV-2. It plays important role in processing viral RNA and, thus evades the host immune system. Therefore, it is of interest to identify mutants of nsp15 amongst Asian SARS-CoV-2 isolates, where a total of 1795 mutations, from 7793 sequences of Asia submitted till 31st January 2022, amongst which A231V, H234Y, K109N, K259R and S261A mutations were found frequent. Hence, we report data on the predicted secondary structure of wild type form followed by hydropathy plot, physiochemical properties, Ramachandran plot, B-cell epitopes prediction and protein modeling of wild type and mutant of nsp15 protein. Data shows that nsp15 of SARS-CoV-2 is a pontential candidate for the development of vaccine to control the infections of SARS-CoV-2.

 

Keywords

SARS-CoV-2, Pandemic, COVID-19, Nsp15, Mutation

 

Citation

Yashvardhini et al. Bioinformation 18(4): 432-437 (2022)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.