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Genome sequence analysis of nsp15 from SARS-CoV-2


Niti Yashvardhini1,*, Deepak Kumar Jha2, Amit Kumar3, Manjush Gaurav3 & Kumar Sayrav4



1Department of Microbiology, Patna Women’s College, Patna, 800 001, Bihar, India; 2Department of Zoology, S.M.P. Girls Degree College, Ballia, 277401, Uttar Pradesh, India; 3Department of Botany, Patna University, Patna-800 005, Bihar, India; 4Department of Chemistry, V.K.S. University, Ara-802301, Bihar India; *Corresponding author





Article Type

Research Article



Received March 1, 2022; Revised April 30, 2022; Accepted April 30, 2022, Published April 30, 2022



SARS-CoV-2 (Severe Acute Respiratory Syndrome), a causative agent of COVID-19 disease created a pandemic situation worldwide. Nsp15 is a uridine specific endoribonuclease encoded by the genome of SARS-CoV-2. It plays important role in processing viral RNA and, thus evades the host immune system. Therefore, it is of interest to identify mutants of nsp15 amongst Asian SARS-CoV-2 isolates, where a total of 1795 mutations, from 7793 sequences of Asia submitted till 31st January 2022, amongst which A231V, H234Y, K109N, K259R and S261A mutations were found frequent. Hence, we report data on the predicted secondary structure of wild type form followed by hydropathy plot, physiochemical properties, Ramachandran plot, B-cell epitopes prediction and protein modeling of wild type and mutant of nsp15 protein. Data shows that nsp15 of SARS-CoV-2 is a pontential candidate for the development of vaccine to control the infections of SARS-CoV-2.



SARS-CoV-2, Pandemic, COVID-19, Nsp15, Mutation



Yashvardhini et al. Bioinformation 18(4): 432-437 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.