HOME   |    PDF   |   


Antioxidant and anti-inflammatory activity of a nanoparticle based intracanal drugs


Iffat Nasim1,*, Marimuthu Shamly1, Krishna Kanth Jaju1, Veeraraghavan Vishnupriya2 & Zohra Jabin3



1Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; 2Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 3Divya Jyoti College of Dental Sciences, Modinagar, Uttar Pradesh, India; *Corresponding author



Iffat Nasim - E-mail: iffatnasim@saveetha.com; Phone: +91 9940063567

M Shamly- E-mail: 152006007.sdc@saveetha.com

KrishnaKanth Jaju- E-mail: 151906008.sdc@saveetha.com

V. Vishnupriya - E-mail: vishnupriya@saveetha.com

Zohra Jabin - E-mail: drzohrajabin@gmail.com


Article Type

Research Article



Received April 27, 2022; Revised May 31, 2022; Accepted May 31, 2022, Published May 31, 2022



The most common intracanal medication is calcium hydroxide. Its efficacy can be affected by a number of factors, including pH, serum proteins, collagen, and dentin. It's also ineffective against E. faecalis and fungus, lacks an anti-inflammatory component, and has mixed reviews when it comes to pain relief. Natural alternatives to synthetic intracanal medication are being researched at the moment. We evaluated the antioxidant and anti-inflammatory activity of green synthesized silver nanoparticle based intracanal medicaments. Silver nanoparticles integrated into calcium hydroxide and graphene oxide nanoparticles were the experimental groups and Calcium hydroxide served as the control. Antioxidant activity was determined using the DPPH and Nitric oxide assays, while anti-inflammatory activity was determined using the protein denaturation and Xanthine Oxidase Inhibition assays. Both experimental groups had higher antioxidant activity than the control group based on DPPH and Nitric oxide assays. Calcium hydroxide combined with silver nanoparticles demonstrated improved anti-inflammatory efficacy in a protein denaturation and Xanthine oxidase inhibition assay. Within the constraints of an in vitro study, it can be concluded that intracanal medicaments containing silver nanoparticles can be employed efficiently during root canal preparation. In comparison to standard calcium hydroxide-based intracanal medicaments, it has effective antioxidant and anti-inflammatory effects.



Antioxidant, anti-inflammatory, activity, nanoparticle, intracanal drugs



Nasim et al. Bioinformation 18(5): 450-454 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.