Title

H-FABP as a diagnostic marker for early detection of young myocardial infarction among Indians

Authors

Anoop Jaiswal¹, Amrita Vamne¹, Manish Kumar Verma² & Beenu Doctor^3,*
 

Affiliation

¹Department of Biochemistry Index Medical College, Malwanchal University Indore, India; ²Department of Biochemistry, GSVM Medical College, Kanpur, India; ³Department of Biochemistry, Moti Lal Nehru Medical College, Prayagraj, India; *Corresponding author
 

Email

Anoop Jaiswal - E-mail: biochemanoop11@gmail.com
Amrita Vamne - E-mail: avamne@gmail.com
Manish Kumar Verma - E-mail: manishverma8919@gmail.com
Beenu Doctor - E-mail: dbeenu.santosh@gmail.com

Article Type

Research Article

Date

Received February 9, 2022; Revised June 30, 2022; Accepted June 30, 2022, Published June 30, 2022

It is of interest to document the point-of-care test using heart-type fatty-acid binding protein (H-FABP) in comparison with CK-MB, Troponin T and hsCRP. This is a more sensitive and specific cardiac biomarker than cTnT and CK-MB, and it has a higher diagnostic effectiveness for detecting early acute myocardial infarction (AMI). The case-control study enrolled 220 participants (110 myocardial infarction patients as cases and 110 healthy subjects as control) > 18 years of either sex after ethical clearance and informed consent form. The study conducted was conducted in the OPD and IPD of Medicine and Biochemistry Department at Moti Lal Nehru Medical College and Swaroop Rani Nehru Hospital Prayagraj, Uttar Pradesh; Index Medical College & Hospital, Malwanchal University, India. The amount of H-FABP, CKMB and cTnT was measured using the Sandwich ELISA method and hs-CRP was evaluated using the immune-turbidimetry method. H-FABP correlation with selected markers (CK-MB, hs CRP and TnT) and CK-MB was significant. A positive correlation (r=0.2 to 0.29) was found when H-FABP was compared with CK-MB (p<0.05). Similar positive correlation was found in CK-MB with cTnT. H-FABP is a useful cardiac marker for the early diagnosis of young AMI and thus prediction of myocardial injury is possible. H-FABP compared with CK-MB showed positive correlation. CK-MB with cTnT also showed statistically significant relation. Thus, H-FABP and CK-MB, as well as the correlation between CK-MB and TnT, reflects utility in early-stage diagnosis of myocardial injury.

Keywords

Human heart-type fatty-acid-binding protein, CK-MB, Troponin T, high-sensitivity C-reactive protein, Young myocardial infarction

Citation

Jaiswal et al. Bioinformation 18(6): 506-512 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.