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Correlation of serum cornitine levels with bone mineral density among Indian male tobacco users


Rashi Chauhan1,*, Amit Kumar Singh1, Manisha Singh1, Richa Shree1, Santosh Anand1, Ashok Kumar Singh1, & Sankalp Verma2



1Buddha Institute of Dental Science And Hospital, Bihar, Patna; 2Minority Dental College And Research Center, Darbhanga, Bihar, India; *Corresponding author



Rashi Chauhan - E-mail: chauhanr83@gmail.com; Phone +91 8294692534
Amit Kumar Singh - E-mail: dramitujjainsingh@gmail.com
Manisha Singh - E-mail: sankalpdentist2004@yahoo.co.in
Richa Shree - E-mail: richashrees@gmail.com
Santosh Anand - E-mail: drsantoshanand0802@gmail.com
Ashok Kumar Singh - E-mail: drsinghashok75@gmail.com
Sankalp Verma - E-mail: sankalpdentist2014@gmail.com


Article Type

Research Article



Received May 2, 2022; Revised June 30, 2022; Accepted June 30, 2022, Published June 30, 2022



It is of interest to assess levels of serum cornitine in male tobacco users and also find its correlation with bone mineral density. Assessment for serum cotinine levels was done using commercially available Enzyme Linked Immunosorbent Assay (ELISA Kit). While bone mineral density was measured using bone densitometry through ultrasound in the wrist region. Karl Pearsonís coefficient was used to assess correlation between BMD values and serum cotinine (ng/ml) levels. Inter group BMD association was measured using Chi square test. The present study showed that the first 3 groups had a low BMD level compared to control group, indicative of osteopenia. BMD values were lesser for chewers from group II as compared to smokers from group I and individuals using both smoked and smokeless form of tobacco from Group III. In group III (both forms of tobacco), osteopenic individuals were more. Thus, data shows effect of tobacco usage on bone mineral density. Smokeless form of tobacco has relatively serious effects on bone density.



Bone mineral density, cotinine, men, tobacco



Chauhan et al. Bioinformation 18(6): 543-546 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.