HOME   |    PDF   |   


Linking leptin in GCF with tooth movement among Indians


Soumyadev Satpathy1,*, Vidyesh Nadkerny2, Shaivi Sharma3, Ayyagari Viresh Goutameshwar4, Sidharth Joshi5 & Vibhuti6



1Department of Dentistry, Fakir Mohan Medical College, Balasore, Odisha 756019, India; 2Department of Orthodontics, Daswani Dental College & Research Centre, Kota, 324001, Rajasthan, India; 3Dept of orthodontics, Bhabha dental college Bhopal - 462001, Madhya Pradesh, India; 4Department of Conservative Dentistry and Endodontics, JSS Dental College and Hospital Mysuru, Mysuru - 570004, Karnataka, India; 5Department of Periodontology, Aditya Dental College, Beed, 431122, Maharastra, India, 6Department of Conservative Dentistry & Endodontics, Maharishi Markendeshwar College of Dental Sciences & Research, Mullana, Ambala - 133203 Haryana, India; *Corresponding author



Soumyadev Satpathy - E-mail: contact.drsoumyadev@gmail.com, dean.fmmchb@gmail.com

Vidyesh Nadkerny - E-mail: drvidyesh@gmail.com

Shaivi Sharma - E-mail: drshaivisharma@gmail.com

Ayyagari Viresh Goutameshwar - E-mail: Vireshayyagari@gmail.com

Sidharth Joshi - E-mail: sidhartjshgmail.com, drass61@gmail.com

Vibhuti - E-mail: endodontist.vibhuti@gmail.com, academic@mmambala.org

K. Anil - E-mail: anilkk44@gmail.com


Article Type

Research Article



Received May 2, 2022; Revised June 30, 2022; Accepted June 30, 2022, Published June 30, 2022



It is of interest to evaluate the association of orthodontic tooth movement with concentration of leptin in Gingival Crevicular Fluid (GCF).Thirty orthodontic patients of both genders with equal sample size were included for the present study. Concentration of leptin was assessed at baseline (T0), 1 hr after application of force (T1), 24 hours later (T2), 7 days after application of force (T3), and 1 month after application of orthodontic force (T4). Using strips of filter paper, GCF was collected from the gingival sulcus on distal aspect of the right maxillary canine. Distalized tooth movement was evaluated by measuring the difference on dental casts, at baseline and one month after force application. One-way ANOVA with Bonferroni correction and Pearson's correlation test were used to analyze the data. Average concentration of leptin in GCF raises from baseline (T0) to 1 hours after application of force (T1), then increased to peak after 24 hours (T2), and declined to a minimum value after 7 days (T3) and again raises after 1 month (T4), closer to the base line value (T0), and this was statistically significant (P < 0.05). There was significant association of the overall average concentration of leptin to degree of tooth movement (correlation coefficient = 0.625). There was a biphasic change in GCF leptin concentration during one cycle of orthodontic force application, thus, a significant association between rates of tooth movement with GCF leptin concentration is noted.



GCF, leptin concentration, orthodontic force, tooth movement



Satpathy et al. Bioinformation 18(6): 572-576 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.