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Anti-inflammatory and cytotoxic effect of lycopene and raspberry in-situ gel


V Mukundh Chaithanya, TN Uma Maheswari* & S Rajesh Kumar



Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India;*Corresponding author



Mukundh Chaithanya V –mukundha2good@gmail.com

TN Uma Maheswari - umamaheswaritn@saveetha.com

S Rajesh Kumar - ssrajeshkumar@homail.com


Article Type

Research Article



Received June 2, 2022; Revised July 31, 2022; Accepted July 31, 2022, Published July 31, 2022



Preparation of an in-situ gel containing lycopene and raspberry plant formulation and analysis of its anti-inflammatory and antioxidant effects is described. Lycopene is known for its anticancer and antioxidant activity. It induces apoptosis, thereby reducing the cancer cells, and also reduces the injury of cells due to oxidative activity. Similarly, raspberry also contains antioxidants properties which can help to reduce oxidative stress and chronic inflammation. This study includes extracts containing 25% of Raspberry and 10% lycopene, carboxymethyl cellulose, hydroxypropyl methyl cellulose, Carbopol, sodium chloride, and distilled water. This in-situ gel was then tested for antioxidant and anti-inflammatory assay using DPPH (2, diphenyl 1-picryl- hydrazyl- hydrate) and bovine serum albumin (BSA), antioxidant assay revealed that the inhibition percentage was more with 50 μL (61.3) of gel and anti-inflammatory assay showed significant results with 10 μL (90.2) of gel. In-situ gel containing lycopene and Raspberry has significant anti-inflammatory and antioxidant activity.



Lycopene, Raspberry, antioxidant, anti-inflammatory



Chaithanya et al. Bioinformation 18(7): 645-650 (2022)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.