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Title

Correlation of inflammatory cytokines and uric acid levels in coronary artery disease with and without type 2 diabetes mellitus

 

Authors

D. Selvakumar1, CK Vijayasamundeeswari1,*, Sandip Sendhav2 & Gnanadesigan Ekambaram3

 

Affiliation

1Department of Biochemistry, Vinayaka Missionís Kirupananda Variyar Medical college and Hospitals , Salem, Vinayaka Missionís Research Foundation (Deemed to be University), Salem -636 308, Tamilnadu, India; 2Department of Biochemistry, Nootan Medical College & Research Centre, Sankalchand Patel University, Visnagar - 384315, Gujarat, India; 3Department of Physiology, Nootan Medical College & Research Centre, Sankalchand Patel University, Visnagar - 384315, Gujarat, India;*Corresponding author

 

Email

D Selvakumar - E-mail:selvarajmscbio@gmail.com

CK Vijayasamundeeswari* - E-mail: biochemistrysalem@gmail.com

Sandip Sendhav - Email: ssendhav_bio@nootanmedical.edu.in

Gnanadesigan Ekambaram - E-mail: edesigan_phy@nootanmedical.edu.in

 

Article Type

Research Article

 

Date

Received July 2, 2022; Revised August 31, 2022; Accepted August 31, 2022, Published August 31, 2022

 

Abstract

Serum levels of inflammatory cytokines such as IL-6, high-sensitivity C-reactive protein as well as uric acids have been considered as predictors of severe outcomes in patients with coronary artery disease (CAD) associated with hypertension (HTN) and Type 2 Diabetes Mellitus (T2DM). Anthropometric parameters were recorded and measured the levels of major risk factors in 80 patients with hypertension, coronary artery disease with and without Type 2 diabetes mellitus and 40 healthy controls were included. Comparison were performed by classifying the study subjects into 3 groups namely- Group I: Controls (n=40); Group II: HTN, CAD without T2DM(n=40); and Group III: HTN,CAD with T2DM(n=40).The values of BMI, weight, SBP, DBP were greater in patients with T2DM CAD group when compared to without diabetes group. Data shows that there is a positive correlation between IL-6, hs-CRP and uric acid concentrations and are statistically significant. The evaluated high levels of inflammatory cytokines and uric acids in hypertensive CAD patients with diabetes might be helpful in the diagnosis of patients at greater risk.

 

Keywords

Coronary artery disease, hs-CRP, Interleukin-6, Type 2 Diabetes Mellitus, Hypertension, Uric acid

 

Citation

Selvakumar et al. Bioinformation 18(8): 675-682 (2022)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.