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Title

In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines

 

Authors

Abraham Sabu1, J. Selvaraj2, R. Gayatridevi1 & E. Dilipan1*

 

Affiliation

1Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India. 2CoMMand, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India; *Corresponding author

 

Email

Abraham Sabu E-mail: abrahamsabuputhu@gmail.com

J. Selvaraj E-mail: selvaraj@saveetha.com

R. Gayatridevi E-mail: gayatridevi@saveetha.com

E. Dilipan E-mail: dilipanev@gmail.com

 

Article Type

Research Article

 

Date

Received January 1, 2023; Revised January 30, 2023; Accepted January 31, 2023, Published January 31, 2023

 

Abstract

The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast cancer cell lines. Because of this, its anticancer effect may be caused by apoptosis, which is caused by DNA breaking and is helped by active phytochemicals like alkaloids, phenols, and flavonoids in the extracts. It also promotes apoptosis by altering Bcl-2 and TGF expression levels. The present study suggests using R. tetraphylla extract as an anticancer agent in traditional medicine. 

 

Keywords

Rauwolfia tetraphylla, breast cancer, cytotoxicity, gene expression, TGF and Bcl1 gene.

 

Citation

     Sabu et al. Bioinformation 19(1): 43-47 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.