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Title |
Molecular docking based design of Dengue NS5 methyltransferase inhibitors
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Authors |
Mohd Adnan Kausar1,*, Abrar Ali1, Samir Qiblawi1, SMA Shahid1, Mohammad Asrar Izhari2 & Anamika Saral3
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Affiliation |
1College of Medicine, University of Hail, Hail, KSA; 2Department of Laboratory Medicine College of Applied Medical Science, Al-Baha University, Saudi Arabia; 3School of studies in Biotechnology, Jiwaji University, Gwalior, Madhya Pradesh, India.
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Mohd Adnan Kausar - Email: adnankausar1@gmail.com; *Corresponding author
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Article Type |
Research Article
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Date |
Received April 17, 2019; Accepted April 23, 2019; Published May 30, 2019
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Abstract |
Dengue is a viral infection caused by RNA infection of the family Flaviviridae and spread by the Aedes mosquitoes. Dengue NS5 methyltransferase is a known drug target for the disease. Therefore, it is of interest to design potential inhibitors for the target using molecular docking analysis. Our analysis shows the binding of compounds STOCK1N-98943, STOCK1N-98872, STOCK1N-98956, STOCK1N-98865, and STOCK1N-98950 with the protein drug target with optimal binding features for further in vitro and in vivo evaluations.
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Keywords |
Dengue, methyltransferase, molecular docking, virtual Screening and IBS.
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Citation |
Kausar et al. Bioinformation 15(6): 394-401 (2019)
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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