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Molecular docking analysis of stevioside with AKT and PPARγ


Abilasha Deenadayalan1,2, S Vijayalakshmi1,*, CS Janaki3 & Selvaraj Jayaraman4



1Department of Anatomy, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Chennai-602105, India; 2Department of Anatomy, Asan Memorial Dental College and Hospitals, Asan Nagar, Chengalpattu, Chennai-602 105, India; 3Department of Anatomy, Bharath Medical College and Hospital, Selaiyur, Chennai-600 073, India; 4Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai- 600 077, India;



Dr. S. Vijayalakshmi - Email: abipriya.papu@gmail.com


Article Type

Research Article



Received January 10, 2020; Revised January 30, 2020; Accepted January 31, 2020, Published January 31, 2021



Stevioside is a diterpenoid glycoside consisting of an aglycone (steviol) and three glucose molecules. It is commonly used as an anti-hyperglycemic food because of its non-caloric property. Therefore, it is of interest to document the interactions of stevioside with AKT & PPAR-γ proteins using Autodock Vina PyRx docking techniques. Results of the docking studies indicate that stevioside had more than two hydrogen bond interactions with the AKT and PPAR γ protein for further consideration.



Diabetes, AKT & PPAR gamma, stevioside, molecular docking



Deenadayalan et al. Bioinformation 17(1): 283-288 (2021)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.