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Linking stress with urocortin in rats



Manikandan Balraj1, Ankamma Sarvepalli2, Bijoya Chatterjee3, Gnanadesigan Ekambaram4, Nithya Rajapandian5, K Nisha6 & Vadivel Mani*



1Department of Physiology, Konaseema Institute Medical Science and Research Foundation, Amalapuram, East Gothawri 533201, Andhra Pradesh, India; 2Department of Anatomy, Konaseema Institute Medical Science and Research Foundation, Amalapuram, East Gothawri 533201, Andhra Pradesh, India; 3Department of Biochemistry, M. P Shah Government Medical College , Jamnagar - 361008 Gujarat, India,4Department of Physiology, Nootan Medical College and Research Center, Sankalchand Patel University, Visnagar - 384315, Gujarat, India, 5Medical physiology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Puducherry - 607402, India,6Department of Community Health Nursing, KIMS Nursing College, KIMS&RF Amalapuram, East Gothwari -533201, Andhra Pradesh, India, *Corresponding author



Manikandan Balraj E-mai: drmani.ayurveda@gmail.com

Ankamma Sarvepalli E-mail: raopalukur@gmail.com

Bijoya Chatterjee E-mail: bijoyalahiri@gmail.com

Gnanadesigan Ekambaram E -mail: edesigan_phy@nootanmedical.edu.in

Nithya Rajapandian E-mail: nithuran@gail.com

Nisha K E-mail: velnisha020214@gmail.com

Vadivel Mani E-mail: velvdm.vel5@gmail.com


Article Type

Research Article



Received November 1, 2023; Revised November 30, 2023; Accepted November 30, 2023, Published November 30, 2023



The corticotropin-releasing factor neuropeptides (CRH and UCN-1,2,3), as well as spexin, contribute to the control of energy balance and limit food intake in mammals. However, the role of these neuropeptides in chronic variable stress remains unknown. The effect of chronic varied stress on circulating corticosterone levels and urocortin expression levels in the brains of experimental rats was studied in this study. Rats were subjected with 28 days long term stress protocol, end of stress protocol experimental and control animal organs isolated, brain urocorcortin-1,2,3 expression by RT-PCR and serum corticosterone by ELISA method. UCN levels in the brain were altered in rats subjected to prolonged varied stress. Furthermore, corticosterone levels were elevated as a result of the same urocortin expression pattern, indicating that urocortin expression is controlled by glucocorticoids via a glucocorticoid-responsive element (GRE). Thus, data shows that hypothalamus-pituitary-adrenal (HPA) axis, also known as the LHPA axis, and limbic system are both stimulated by stress, which is reflected in the form of elevated corticosterone levels, according to the genes UCN1, 2, and 3.



Chronic variable stress, urocortin, corticotrophin-releasing factor, HPA-axis



Balraj et al. Bioinformation 19(11): 1057-1062 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.