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Effect of curcumin, betadine and chlorhexidine in gingival wound healing



Ankita Agrawal1, Rashmi Kiran Ekka2, Deepika Singla3*, Patiksha Kumar4, Deepak Kochar5, Ruhi Sidhu6, Bharat Gupta7 & Kapil Paiwal8



1Department of Conservative and Endodontics, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India; 2Department of Oral Medicine and Radiology, Bhabha College of Dental Sciences, Bhopal, MP, India; 3Department of Conservative Dentistry & Endodontics, Desh Bhagat Dental College & Hospital, Mandi Gobindgarh, Punjab, India; 4Department of Oral Pathology & Microbiology, Government College of Dentistry, Indore, M.P., India; 5Department of Periodontology, M.M. College of Dental Sciences & Research, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India; 6Oral Medicine and Radiology, MNDAV Dental College and Hospital, Tatul, Oachghat, Solan, Himachal Pradesh, India; 7Department of Periodontics, MGM Dental College, Navi Mumbai, India;8Department of Oral & Maxillofacial Pathology, Daswani Dental College & Research Center, Kota, India



Ankita Agrawal - E-mail:agrawalankita008@gmail.com; Phone: +91 9006284360

Rashmi Kiran Ekka - E-mail:drrashmi4876@gmail.com; Phone: +917024124076

Deepika Singla - E-mail:dsingla2810@gmail.com; Phone: +91 9888624200

Patiksha Kumar - E-mail:dr.pratiksha.kumar@gmail.com; Phone: +91 98262 77022

Deepak Kochar - E-mail:drdeepakkochar@mmumullana.org; Phone: +919991099901

Ruhi Sidhu - E-mail:ruhi.sidhu@yahoo.com; Phone: +91 98550 67639

Bharat Gupta - E-mail:guptabhar@gmail.com; Phone: +91 90299 75452

Kapil Paiwal - E-mail:drpaiwal@gmail.com; Phone: +91 80006 75259


Article Type

Research Article



Received December 1, 2023; Revised December 31, 2023; Accepted December 31, 2023, Published December 31, 2023



The effect of chlorhexidine (CHX) digluconate, Betadine (BET), curcumin (CUR) on gingival wound healing is of interest to dental practitioners. Hence, we studied the average fibroblast viability % for each of the concentrations of CUR, BET and CHX over various time durations. It was found that mean percentage of viability of fibroblasts is high in CUR and low in CHX at all time periods while the mean percentage of viability of fibroblasts in BET 1% was greater than CHX but lower than CUR at all time periods. Thus, curcumin at a concentration of 0.003% demonstrates the least cytotoxicity for fibroblasts. Hence, it is the most effective bacterial suppression, and the best wound healing.



Curcumin, chlorhexidine, human fibroblast viability, migration



Agrawal et al. Bioinformation 19(12): 1153-1158 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.