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Nootropic activity of methanolic extract from Evolvulus alsinoides Linn. in mice with scopolamine-induced amnesia



Karnam Nithya1,*, Rajaram Siddaraman2, PP Sheelajoice3, Mani Rajarathinam4 & Vurimi Bhopal Chandra5



1Department of Pharmacology, Vinayaka Missions University, Salem, Chinna Seeragapadi, Salem - 636308, Tamilnadu, India; 2Department of Pharmacology, VMKV Medical College, Chinna Seeragapadi, Salem - 636308, Tamil Nadu, India; 3Department of Physiology, VMKV  Medical College, Chinna Seeragapadi, Salem - 636 308, Tamil Nadu, India; 4Department of Pharmacology, GMKMC Medical College, Shavapet Salem 636002, Tamil Nadu, India; 5Department of Pharmacology, Narayana Medical College, Nellore - 524 003, AP, India;



Karnam Nithya - E-mail: nithyasree13@gmail.com

Rajaram Siddaraman - E-mail: drrjrm@gmail.com

PP Sheelajoice - E-mail: sheelapaul05@gmail.com

Mani Rajarathinam - E-mail: drmanivp@gmail.com

Vurimi Bhopal Chandra - E-mail: bhopalchandra@gmail.com


Article Type

Research Article



Received December 1, 2023; Revised December 31, 2023; Accepted December 31, 2023, Published December 31, 2023



Plants have been used as therapeutic agents in both un-ionized (Unani, Ayurveda) and unstructured forms since ancient times. Therefore, it is of interest to document the nootropic activity of methanolic extract from Evolvulus alsinoides Linn (Vishnukranthi) in mice with scopolamine-induced amnesia. Healthy male Swiss albino mice ranging between 25 and 30 g were used in the study. Scopolamine induced amnesia, the following two tests are performed, elevated plus maze test, passive avoidance test. The mean time spent in the open arm, closed arm, and central platform for each group of animals. The total transitions were 12.60.89 by GS group mice, 3.40.55 by GSP group mice, 70.71 by GSLD group mice and 100.71 by GSHD group mice. A significant difference was seen between GS and GSP group mice means. The mean time in the safe zone and shock zone for each group of animals when comparing to Group 2 Vs Group 3, 4 showed a statistical significance of p < 0.05. The findings of this study suggest that Evolvulus alsinoides may be a promising candidate for the development of new treatments for memory impairment and other cognitive disorders. It should be noted that more data is needed to confirm the safety and efficacy of Evolvulus alsinoides in humans and to investigate its long-term effects.



Nootropic activity, methanolic extract, Evolvulus alsinoides Linn, vishnukranthi, scopolamine.



Nithya et al. Bioinformation 19(12): 1212-1216 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.