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Platelet-rich fibrin and titanium-prepared platelet-rich fibrin in endoperio lesion management


Balram Choudhary1, Komal Goswami2*, Bhumika J Patel3, Ansee R Vaghani4, Dhurubatha J5, Nishita Grandhi6 & Ramanpal Singh Makkad7



1Department of Dentistry, JLN Medical College & Hospital, Ajmer, Rajasthan, India; 2Department of Dentistry, Kshetrapal Hospital, Ajmer, Rajasthan, India; 3Department of Oral Medicine & Radiology, Gujarat, India, 4BDS, Gujarat, India; 5Department of Oral and Maxillofacial Surgery, Government Dental College, Kadapa, AP, India; 6Department of Conservative and Endodontics, New Horizon Dental college and Research institute, Bilaspur, Chhattisgarh, India; 7Department of Oral Medicine and Radiology, New Horizon Dental college and Research institute, Bilaspur, Chhattisgarh, India; *Corresponding author;



BalramChoudhary E-mail:balrams83@gmail.com; Phone: +91 9461464171

Komal Goswami E-mail: drkomal1915@gmail.com; Phone: +91 9828284481

Bhumika J Patel E-mail: bhumikapatel2687@gmail.com; Phone: +91 7041239412

Ansee R Vaghani E-mail: avagh708@gmail.com; Phone: +91 7624047380

J Dhurubatha E-mail: dhurubatha@gmail.com; Phone: +91 8696955758

Nishita Grandhi E-mail: nishi.grand@gmail.com; Phone: +91 9964567567

Ramanpal Singh Makkad E-mail: drramanpal@gmail.com; Phone: +91 9098699300

Vini Mehta - vinip.mehta@gmail.com


Article Type

Research Article



Received January 1, 2023; Revised January 30, 2023; Accepted January 31, 2023, Published January 31, 2023



Endo-perio lesions involve a variety of therapy choices that will lead to the best possible elimination of infection. Various therapy approaches have been investigated for curing of patients affected by endo-perio abnormalities. One of the second-generation platelet derivatives is plasma enriched with platelet (PRP).They may aid in the healing of wounds. Enhanced with platelets cells and several growth factors, platelet-rich fibrin (PRF) promotes repair and healing and regeneration of tissue at the periapical area. Platelet cell and leukocyte cell enriched fibrin, prepared in conjunction with titanium (T-PRF), is analogous to fibrin made using the traditional PRF process.The current study was undertaken to compare PRF against T-PRF in the therapy of endo-perio abnormalities using the basic information that was available.280 patients of all sexes between the ages of 18 years and 58 years make up the study's participants. They were divided into two categories. In category I study participants PRF was employed to fill the defect created due to pathology and in category II patients, a T-PRF was used, accompanied by suturing. The one walled, two walled, and three-wall walled infrabony abnormalities were quantified on the digital images acquired using the grid. After three months and six months, the probing periodontal pocket depth in mm and level of attachment (RAL) in mm were measured. In category one, mean change at 3 months was 3.21mm accounting for 33.79% change in PPD. On the other hand mean change at 6 months was 3.61mm accounting for 43.79% change in PPD.  When there was evaluation in study participants in category two then it was observed that mean change at 3 months was 2.02mm accounting for 34.79% change in PPD. On the other hand mean change at 6 months was 3.62 mm accounting for 44.79% change in PPD. There was reduction of depth of periodontal pocket at both 3 months follow up and 6 months follow in both categories; however there was no statistical significant variation observed between the two categories regarding decrease in the depth of periodontal pocket on analysis of intergroup variations. It was concluded that there was increase in periodontal attachment and decrease in depth of periodontal pocket in both PRF and T-PRF however there was no statistical substantial variation observed between the two categories regarding increase in the attachment level or decrease in depth of periodontal when intergroup variations between PRF and T-PRF were considered. 



Endo-perio lesions; platelet-rich fibrin, titanium-prepared platelet-rich fibrin.



Choudhary et al. Bioinformation 19(1): 133-137 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.