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Association of obesity and insulin resistance to gestational diabetes mellitus



Swathi Thilak1, Aishwarya Rajendra2,* & Veluri Ganesh3   



1SS Institute of Medical Sciences, Davanagere, Karnataka, India; 2 Department of Obstetrics and Gynaecology, Mavintop Hospital and IVF Center, Davangere, Karntaka 577004, India; 3Department of Biochemistry, Akash Institute of Medical Sciences and Research Centre, Bangalore - 562110, India; *Corresponding author



Swathi Thilak E-mail: swathi91thlk@gmail.com 

Sapna Laxman Dandin E-mail:   sldandin21@gmail.com

Aishwarya Rajendra E-mail:  aishuraju16993@gmail.com

(hospital website: www. Mavintop Hospital.com)

Veluri Ganesh E-mail: ganeshbabu370@gmail.com


Article Type

Research Article



Received February 1, 2023; Revised February 28, 2023; Accepted February 28, 2023, Published February 28, 2023



Gestational diabetes mellitus is most commonly observed in pregnant women and it was significantly linked with dyslipidemia, obesity and insulin resistance. The present study aimed to evaluate the association of obesity, insulin resistance risk of gestational diabetes mellitus. This cross sectional study included total ninety (90) subjects out of this 30 subjects with 1st trimester, another 30 subjects were considered 2nd trimester and remaining 30 were 3rd trimester. The fasting, post parandial blood sugars, glycated haemoglobin, lipid profile and insulin levels were measured and data was recorded. There was a significantly elevated levels of fasting and post parandial blood sugars, glycated haemoglobin, total cholesterol, triacylglycerol, very low density lipoprotein, low density lipoprotein (p = 0.0001**) in all the trimesters of gestational diabetes mellitus subjects. Additionally, we also observed significantly decreased levels of high density lipoprotein, insulin and HOMA-IR (p = 0.0001**) in all the trimesters of gestational diabetes mellitus subjects. The present study IR raises as the pregnancy progresses and it is linked to bad outcomes for both the mother and the fetus. All trimesters of gestational diabetes mellitus should be screened for IR, and early treatment may assist to lessen the resulting difficulties.



Gestational diabetes mellitus, insulin resistance, HOMA-IR



Thilak et al. Bioinformation 19(2): 211-214 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.