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Title

Salivary physicochemical characteristics and antimicrobial human peptide among Indian children with dental caries

 

Authors

RM Vatchala Rani1, Neha Singh*2, Swati Murmu3, Abhishek4, Sakshi Raina5 & Shalini Singh6

 

 

Affiliation

1Department of Oral Pathology and Microbiology Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India, 2Tutor, Department of Periodontology, Dental College, Rims, Ranchi, Jharkhand, India, 3Post Graduate Student, Department of Paediatric and Preventive Dentistry, Hazaribag College of Dental Sciences and Hospital, Hazaribagh, Jharkhand, India, 4Private Practioner, Oral and Maxillofacial Surgeon, Oro Care Facial Trauma Centre, Patna, Bihar, India, 5Department of Orthodontics, Dental Officer, Echs Polyclinic (Ministry of Defence) Samastipur, Bihar, India, 6Senior Resident, Department of Pedodontist, Safdarjung Hospital, New Delhi, India; *Corresponding author; Communicated by Vini Mehta

 

Email

Vatchala Rani RM - E-mail: rvatchala@jmi.ac.in; Phone: +91 9818415290

Neha Singh - E-mail: drnehasinghrajput@gmail.com; Phone: +91 9661407612

Swati Murmu - E-mail: swatimurmu289@gmail.com; Phone: +91 8294542680

Abhishek - E-mail: drabhishek690@gmail.com; Phone: +91 9334154553

Sakshi Raina - E-mail: drsakshiraina3@gmail.com; Phone: +91 6005124163

Shalini Singh - E-mail: drshalini.singh826@gmail.com; Phone: +91 9910045575

Vini Mehta - vinip.mehta@gmail.com

 

Article Type

Research Article

 

Date

Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023

 

Abstract

Salivary innate defenses encompass mechanical cleaning, calcium phosphate salts and fluoride ion reduction of enamel dissolution rate, buffering capacity and neutralizing capacity, and antibacterial properties employing antimicrobial substances like antimicrobial peptides, agglutins, lactoferrin, lactoperoxidase, lysozyme and immuno globulins. Antimicrobial peptides play a key role in the initial defensive responses that make up innate immunity. The aim of this study was to assess the relationship between salivary physicochemical characteristics like buffering capacity, pH, flow rate, and concentrations antimicrobial human peptide like HBD-3, HNP13 and LL-37 and caries activity in young children. Before to collecting the samples, informed permission papers were gathered and completed by the children's legal guardians or parents. There was significant correlation showing reduced caries activity on increased concentrations of HNP1-3. When there was analysis of correlation of CAS with LL-37 concentrations then the p value vas 0.002 showing the correlation was significant. There is significant relationship between salivary physicochemical characteristics like buffering capacity, pH, flow rate, and concentrations antimicrobial human peptide like HBD-3, HNP13 and LL-37 and caries activity in young children.

 

Keywords

Saliva, caries activity, physiochemical properties, defensive peptides

 

Citation

Rani et al. Bioinformation 19(4): 428-432 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.