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Effect of lupeol on insulin resistance in adipose tissue by modulating the expression of insulin and inflammatory signaling molecules in high-fat diet and sucrose-fed diabetic rats



Priscilla Daniel1, TM Vijayalakshmi1* & Madhan Krishnan2



1Department of Medical Biochemistry, Dr. A.L.M PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India. 2Assistant Professor, Research, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam- 603103, Tamilnadu, India;


Priscilla Daniel - E-mail: danielpriscilla4@gmail.com

TM Vijayalakshmi E-mail: proftmvijayalakshmi@gmail.com

Madhan Krishnan - E-mail: kmadhan91@gmail.com


Article Type

Research Article



Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023



The prevalence of obesity and diabetes has increased globally as a result of lifestyle modifications including eating a high-fat diet and not exercising. The target tissues to insulin action are the key pathophysiological event contributing to the development of type 2 diabetes mellitus. The treatments for type 2 diabetes that are now accessible are ineffectual due to their unfavourable side effects. Hence, search drugs, from plant sources. Lupeol is widely present in various medicinal plants. It has been reported to elicit multitude of bioactivities including antilipidemic and antihyperglycemic activity. However, specific effect of Lupeol on insulin signaling molecules of adipose tissue remains unclear. Hence, the study aimed to assess the beneficial role of Lupeol on the expression of insulin‑signaling molecules in adipose tissue of high fat diet and sucrose-induced type‑2 diabetic rats. The oral effective dose of lupeol at a dose of 25 mg per kg body weight per day orally for 30 days is observed. Lupeol, being a powerful antioxidant agent, normalises hyperglycemia, dyslipidaemia, and hyperinsulinemia while also suppressing oxidative stress by scavenging high levels of ROS. It also enhances insulin signalling in type 2 diabetic rats in adipose tissues. Lupeol administration decreased the levels of pro-inflammatory cytokines, which may be due to lupeol's possible antioxidant and anti-inflammatory activities, and thus it promotes insulin sensitivity via altering pro-inflammatory signalling molecules in adipose tissue such as IL-6, TNF alpha, and NFkB. As a result of the current findings, it is concluded that lupoel possesses potent anti-diabetic characteristics and could be used as a phytomedicine for the treatment of type 2 diabetes.



Type 2 diabetes; lupeol; high fat diet; sucrose; adipose tissue



Daniel et al. Bioinformation 19(4): 445-453 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.