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Title

Molecular docking analysis of proflavin with the Wnt pathway targets for OSCC

 

Authors

Jayanthi Pazhani, Vishnu Priya Veeraraghavan & Selvaraj Jayaraman*

 

Affiliation

Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai-600077, India; *Corresponding author

 

Email

Jayanthi Pazhani E-mail: drjayanthip@gmail.com

Vishnu Priya Veeraraghavan E-mail: vishnupriya@saveetha.com

Selvaraj Jayaraman E-mail: selvarajj.sdc@saveetha.com

 

Article Type

Research Article

 

Date

Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023

 

Abstract

Wnt signaling pathway plays a critical role in tumor progression and metastasis of various cancer types. Therefore, it is of interest to document the molecular docking analysis of proflavin with the Wnt pathway targets (GSK3β, β-catenin, and VIM) for oral squamous cell carcinoma (OSCC). These results suggest that targeting the wnt signaling downstream targets with proflavine might leads to the better outcome for therapeutic outcome for the inhibition of invasion and metastasis in oral squamous cell carcinoma.

 

Keywords

Oral carcinoma, wnt signaling, proflavine, molecular docking.

 

Citation

Pazhani et al. Bioinformation 19(4): 464-466 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.