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Molecular docking analysis of cetuximab with NOTCH signalling pathway targets for oral cancer



Jayanthi Pazhani, Vishnu Priya Veeraraghavan & Selvaraj Jayaraman*



Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai-600077, India; Corresponding author*



Jayanthi Pazhani - drjayanthip@gmail.com

Vishnu Priya Veeraraghavan -drvishnupriyav@gmail.com

Selvaraj Jayaraman - selvarajj.sdc@saveetha.com


Article Type

Research Article



Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023



Notch signaling is an evolutionarily ancient mechanism which intricated in cell–cell communication and it plays a crucial role in various developments in malignancies. Inactivating mutations of NOTCH targets are present in about 10 % of cases of squamous cell carcinoma of the skin, oral cavity, and esophagus that rendering it one of the most frequently mutated genes in oral squamous cell carcinoma. Therefore, it is of interest to document the molecular docking analysis of cetuximab with the NOTCH signaling targets such as NOTCH1, NICD, and HES1. These results suggest that targeting the NOTCH signaling with cetuximab might leads to the better outcome for suppression of invasion and metastasis in oral carcinoma.



Oral carcinoma, NOTCH signaling, Cetuximab, molecular docking.



Pazhani et al. Bioinformation 19(4): 471-473 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.