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Title

STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota

 

Authors

Karthickraj Selladurai1, Sahana Selvaganesh1*, Vishnu Priya Veeraraghavan2, Thiyaneswaran Nesappan1 & Rajalakshmanan Eswaramoorthy3*

 

Affiliation

1Department of Implantology1, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Medical and Technical Sciences, Saveetha University, Chennai 600077, India; 2Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Medical and Technical Sciences, Saveetha University, Chennai 600077,India; 3Department of Biomaterials, Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Medical and Technical Sciences, Saveetha University, Chennai 600077, India; *Corresponding author

 

Email

Karthickraj Selladurai E-mail: skarthickraj3@gmail.com

Sahana Selvaganesh E-mail: sahanaselva4@gmail.com

Vishnu Priya Veeraraghavan E-mail: vishnupriya@saveetha.com

Thiyaneshwaran Nesappan E-mail: dr.thiyan@gmail.com

Rajalakshmanan Eswaramoorthy E-mail: rajalakshmanane.sdc@gmail.com

 

Article Type

Research Article

 

Date

Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023

 

Abstract

Glycyrrhizin is present in the root extract of the licorice plant used for various conditions, including gastric ulcers. Therefore, it is of interest to document the STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota. The peri implant pathogens includes Aggregatibacter actinomycetemcomitans (D7S-1), Centipeda periodontii, Campylobacter gracilis, Fusobacterium nucleatum, Slackia exigua, Prevotella intermedia, Tannerella forsythia, Staphylococcus aureus, Bacteroides fragilis, and Bacteroides fragilis. Hence, a user-defined query was used to conduct analysis on the provided bacterial strains whose molecular data available in the STITCH database. Thus, we used the STITCH tool to examine protein interactions and the VirulentPred tool to assess pathogenicity using the known molecular data on glycrhizzin and peri implant pathogens. Data shows that glycyrrhizin interacts with peri implant pathogens.

 

Keywords

Glycyrrhizin, in vitro, prediction, peri-implant microbes, peri implantitis.

 

Citation

Selladurai et al. Bioinformation 19(4): 499-501 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.