Title

STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota

Authors

Karthickraj Selladurai¹, Sahana Selvaganesh^1*, Vishnu Priya Veeraraghavan², Thiyaneswaran Nesappan¹ & Rajalakshmanan Eswaramoorthy^3*

Affiliation

¹Department of Implantology¹, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Medical and Technical Sciences, Saveetha University, Chennai 600077, India; ²Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Medical and Technical Sciences, Saveetha University, Chennai 600077,India; ³Department of Biomaterials, Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Medical and Technical Sciences, Saveetha University, Chennai 600077, India; *Corresponding author

Email

Karthickraj Selladurai – E-mail: skarthickraj3@gmail.com

Sahana Selvaganesh – E-mail: sahanaselva4@gmail.com

Vishnu Priya Veeraraghavan – E-mail: vishnupriya@saveetha.com

Thiyaneshwaran Nesappan – E-mail: dr.thiyan@gmail.com

Rajalakshmanan Eswaramoorthy – E-mail: rajalakshmanane.sdc@gmail.com

Article Type

Research Article

Date

Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023

Glycyrrhizin is present in the root extract of the licorice plant used for various conditions, including gastric ulcers. Therefore, it is of interest to document the STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota. The peri implant pathogens includes Aggregatibacter actinomycetemcomitans (D7S-1), Centipeda periodontii, Campylobacter gracilis, Fusobacterium nucleatum, Slackia exigua, Prevotella intermedia, Tannerella forsythia, Staphylococcus aureus, Bacteroides fragilis, and Bacteroides fragilis. Hence, a user-defined query was used to conduct analysis on the provided bacterial strains whose molecular data available in the STITCH database. Thus, we used the STITCH tool to examine protein interactions and the VirulentPred tool to assess pathogenicity using the known molecular data on glycrhizzin and peri implant pathogens. Data shows that glycyrrhizin interacts with peri implant pathogens.

Keywords

Glycyrrhizin, in vitro, prediction, peri-implant microbes, peri implantitis.

Citation

Selladurai et al. Bioinformation 19(4): 499-501 (2023)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.