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Title

Gene expression analysis of alkaline phosphatase in peri-implantitis tissue

 

Authors

Saumya Mehta1, Subhashree Rohinikumar*1, Abhinav Rajendra Prabhu1, Thiyaneswaran Nesappan1, Vishnu Priya Veeraraghavan2 & Rajalakshmanan Eswaramoorthy*3

 

Affiliation

1Department of Implantology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India; 2Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India. 3Department of Biomaterials, Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Medical and Technical Sciences, Saveetha University, Chennai 600077, India; *Corresponding author

 

Email

Saumya Mehta E-mail: saumyamehta0027@gmail.com

Subhashree Rohinikumar E-mail: subhashreer.sdc@saveetha.com

Abhinav Rajendra Prabhu E-mail: trilokabhinav@gmail.com

Thiyaneswaran Nesappan E-mail: dr.thiyan@gmail.com

Rajalakshmanan Eswaramoorthy E-mail: rajalakshmanane.sdc@saveetha.com

Vishnu Priya Veeraraghavan E-mail:vishnupriya@saveetha.com

 

Article Type

Research Article

 

Date

Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023

 

Abstract

Peri-implantitis is a condition that causes inflammation and bone loss around dental implants. Alkaline phosphatase (ALP) is a gene involved in the inflammation of the tissue. Therefore, it is of interest to evaluate the expression of the ALP gene around the peri-implantitis site. 20 samples were collected and analyzed using qRT-PCR, and statistical analysis was performed. The results showed a significant decrease in ALP expression in infected peri-implantitis tissue compared to normal tissue, indicating that ALP gene is involved in the inflammation of peri-implantitis and correlates with clinical findings.

 

Keywords

Alkaline phosphatase, Peri-implantitis, Polymerase Chain Reaction, mineralization

 

Citation

Mehta et al. Bioinformation 19(4): 506-509 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.