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Formulation and evaluation of a novel herbal trio gel containing flax seed extract, carbopol and carboxymethyl cellulose



P Swarna Meenakshi, Sankari Malaippan* & Rajeshkumar Shanmugam



Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India, *Corresponding author



P Swarna Meenakshi E-mail: swarnameenakshi1996@gmail.com; Phone: +91 9578983680

Sankari Malaippan E-mail: sankari@saveetha.com; Phone: +91 9840285905

Rajeshkumar Shanmugam E-mail: rajeshkumars.sdc@saveetha.com; Phone: +91 9629739263


Article Type

Research Article



Received May 1, 2023; Revised May 31, 2023; Accepted May 31, 2023, Published May 31, 2023



It is of interest to formulate and evaluate herbal trio gel containing brown flax seed extract, carbopol, and carboxymethyl cellulose and to assess the antimicrobial, anti-inflammatory activity along with quality analysis using SEM and FTIR. The brown flax seeds were grinded into a fine powder and supercritical fluid was prepared which was mixed with CMC and carbopol. The formulation was checked for antimicrobial, anti-inflammatory activity, surface characteristics with SEM and FTIR. The results revealed that the antimicrobial activity of the trio gel was efficacious in hampering the growth of black pigmented anaerobes. The highest zone of inhibition for novel herbal trio gel was recorded at 100 μL measuring 14mm and for the standard chlorhexidine gel it was recorded at 100 μL measuring 23mm in diameter. The results proved that the zone of inhibition of novel herbal trio gel had a decent difference to that of standard chlorhexidine gel. The anti-inflammatory activity showed significant activity at 20 μL which accounted for 53% for the novel herbal trio gel and for the standard diclofenac gel it showed highest activity at 20 μL which accounted for 60%. However, there was not much difference between the herbal trio gel and standard diclofenac gel. SEM observations revealed that the components used in formulation of this trio gel have been bonded well to each other and exhibited appreciable surface characteristics.  The lattice of the trio gel has been very well exhibited in SEM analysis. FTIR revealed high peaks showing the different components present in the trio gel. Within the limitations of the study, the results of our study concluded that novel herbal trio gel containing Linum usitatissimum extract, sorbitol, and carboxymethyl cellulose could be an efficient economic primeval substitute that is non-toxic, natural, and structured for clinical application.



Flax seed extract, periodontitis, herbal intervention, SEM, FTIR, well-being, diseased.



Meenakshi et al. Bioinformation 19(5): 540-545 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.