HOME   |    PDF   |   


Deterioration of lung function and its association with eosinophil count



Bama Rajanayagam1, 2, Sundaramahalingam Manikandan*3, & Nag Anand4



1Bharath Institute of Higher Education and Research, Selaiyur, Chennai, India; 2Dept. of Physiology, Indira Medical College and Hospital, Thiruvallur, Tamilnadu, India;, 3Dept. of Physiology, Tagore Medical College and Hospital, Rathinamangalam, Chennai, India; 4Dept. of General Medicine, Sree Balaji Medical College and Hospital, Chromepet, Chennai, India; *Corresponding Author



Bama Rajanayagam - E-mail: pdcbama@gmail.com

S Manikandan - E-mail: drsmanikandan@gmail.com

NN Anand - E-mail: anandnmd@gmail.com


Article Type

Research Article



Received May 1, 2023; Revised May 31, 2023; Accepted May 31, 2023, Published May 31, 2023



Exposure to lethal dust particles has a negative impact on human’s health. This work investigated the association between respiratory symptoms and eosinophil levels between quarry workers and the controls.  A total of 75 workers exposed to quarry dust and 45 age, sex, body mass index-matched unexposed controls participated in this study. Results of this study indicated that the quarry dust particles  produced  inflammatory responses,  increasing the mean  eosinophil level (7.56 ± 2.94), causing allergic  respiratory symptoms  such as  rhinitis , chest tightness, wheeze, sputum production thus impairing the lung function with  decline in FEV1(80.84 ±108.8) level  in workers exposed to quarry dust compared to controls (P≤0.00**) Conclusion: The presence of increased levels of respiratory irritants in quarry sites may explain the higher prevalence of respiratory infections and exacerbated inflammatory reactions  found to ascertain the link between  increased eosinophil count and the lung impairment in quarry workers.



Eosinophil count, Deterioration,lung function



Rajanayagam et al. Bioinformation 19(5): 644-648 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.