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Title

Assessment of segmental lung involvement in covid-19 patients using biochemical parameters

 

Authors

T. Siva1, Yuvaraj Maria Francis2, PK Sankaran3,*, CP Kirthika1, Vinoth Kumar Kalidoss4, R Sarah5, K Hemanth3 & Madhan Krishnan6

 

Affiliation

1Department of Anatomy, Sri Ramachandra Institute of Higher Education and Research, Chennai- 600 116, India; 2Department of Anatomy, Saveetha Medical College, Saveetha institute of medical and technical sciences, Thandalam, Chennai- 602 105, India; 3Department of Anatomy, All India Institute of Medical Sciences (AIIMS) Mangalagiri, Andhra Pradesh- 522 503, India; 4Department of community & Family Medicine, All India Institute of Medical Sciences (AIIMS) Mangalagiri, Andhra Pradesh- 522 503, India; 5Department of Anatomy, All India Institute of Medical Sciences (AIIMS) Madurai, Tamil Nadu 625 008, India; 6Research, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam-603103, Tamilnadu, India; *Corresponding author

 

Email

PK Sankaran - E-mail: drpks@live.com

T Siva - E-mail:  siva17187@gmail.com

Yuvaraj Maria Francis - E-mail: sujinalways@gmail.com   

CP Kirthika - E-mail: cpkirthika@gmail.com

K  Vinoth Kumar - E-mail: vinob4u@gmail.com  

R Sarah - E-mail: drsarahsenthilkumar@gmail.com

K Hemanth - E-mail: hemanth.kommuri@gmail.com

Madhan Krishnan - E-mail: kmadhan91@gmail.com

 

Article Type

Research Article

 

Date

Received June 1, 2023; Revised June 30, 2023; Accepted June 30, 2023, Published June 30, 2023

 

Abstract

This study is to investigate the segmental involvement of lung in COVID-19 individuals using high resolution computed tomography (HRCT) and to correlate with serum inflammatory markers. Retrospective study done in 100 COVID 19 RTPCR positive patients with radiological images were collected and analyzed for lobar involvement, bronchopulmonary segments in 3D and CT Scores and it was compared with serum inflammatory markers (SIM). Variables like gender, involvement of segments and co-morbid conditions were summarized as frequency and percentage. Sub group analysis was done using independent t test, Chi-Square. Findings revealed that males were commonly affected than females with the mean age 57.47 13.0. Lower lobes and posterior basal segment of both the lungs were affected with preponderance on the left side. Additionally, SIM were up regulated in the COVID-19 individuals. Serum IL-6, D-dimer and Ferritin showed upsurge in right lung and CRP and LDH elevated in left lung in the COVID-19 and it was statistically correlated with CT severity score. Chest HRCT and biochemical parameters individually and in combination help in identifying the COVID 19 severity among individuals for preventing or reducing the mortality rate in adults.

 

Keywords

COVID 19, HRCT, ground glass opacity, IL-6, D-dimer, ferritin, CRP and LDH

 

Citation

      Siva et al. Bioinformation 19(6): 739-744 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.