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Antimicrobial properties of green synthesized silver and chitosan nanocomposites



S Dhevishri1, B Devi Parameswari2*, Annapoorni Hariharan3, MS Sathya Shankar4 & S Rajesh Kumar5



1Department of Prosthodontics, MAHER, Chennai, India; 2,*Department of Prosthodontics, MAHER, Chennai, India; 3Department of Prosthodontics, MAHER, Chennai, India; 4Department of Prosthodontics, MAHER, Chennai, India; 5Department of Pharmacology, Saveetha dental college, SIMATS, Chennai, India; *Corresponding author



S Dhevishri - E-mail: dhevishri510@gmail.com

B Devi Parameswari - E-mail: drdevi.prostho@madch.edu.in

Annapoorni Hariharan E-mail: profhod.prostho@madch.edu.in

MS Sathya Shankar - E-mail: drsathya.prostho@madch.edu.in

S Rajesh Kumar - E-mail: rajeshkumars.sdc@saveetha.com 


Article Type

Research Article



Received June 1, 2023; Revised June 30, 2023; Accepted June 30, 2023, Published June 30, 2023



An eco-friendly and simple approach was carried out for the synthesis of silver-chitosan nanocomposites using Azadirachta indica and fluconazole-mediated aqueous extract. This extract acted as a reducing agent as well as a capping agent for the green synthesis of silver nanoparticles. Chitosan nanoparticles on the other hand were synthesized from the deacetylation of the chitin matrix. To confirm the nanoparticle synthesis, a UV- A visible spectrophotometer was used and FTIR analysis confirmed the presence of functional groups in the prepared extract. The morphological characteristics of silver and chitosan nanoparticles and as nano-composites were studied and confirmed using scanning electron microscopy (SEM) analysis. The synthesized silver-chitosan nanocomposites were subjected to well-loaded agar plates for the evaluation of antibacterial properties against the Streptococcus mutans and Candida albicans for their antifungal properties. The synthesized silver and chitosan nanoparticles showed antibacterial and antifungal activities against common oral micro flora such as Streptococcus mutans and Candida albicans which were measured using the zone of inhibition method. This approach is a one-step, economical and eco-friendly, biocompatible, and effective alternative for nanoparticle synthesis for various prosthetic applications.



Nanoparticles; silver; chitosan; green synthesis; antimicrobial; nano-composites



Dhevishri et al. Bioinformation 19(6): 745-748 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.