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Title

Structural elucidation of a compound extracted from Streptomyces Sp. NLKB45

 

Authors

B Sudha Kalyani1,4, B Amrutharaj2 , PS Krishna3 & K Sreenivasulu4*

 

Affiliation

1IKP-Lifescience Incubator, Hyderabad, Telangana, India; 2Department of Pharmaceutical Analysis, NIPER, Punjab, India; 3Lavin Laboratories, Hyderabad, Telangana, India; 4Department of Biotechnology, KLEF University, Guntur District, A.P., India;* corresponding author.

 

Email

B Sudha Kalyani E-mail: sudhakalyanib@gmail.com

B Amrutharaj - E-mail: amruthraj02oct@gmail.com

PS Krishna - E-mail: shiva_krishnapabba@yahoo.com;

K Sreenivasulu - E-mail: nikhi_bt@kluniversity.in

 

Article Type

Research Article

 

Date

Received July 1, 2023; Revised July 31, 2023; Accepted July 31, 2023, Published July 31, 2023

 

Abstract

A Streptomyces Sp. NLKB45 was isolated from the Nellore coastal region. After checking antimicrobial and antifungal activity the strain was subjected to fermentation in starch casein broth medium. HPLC was used to purify the culture filtrate after it had been extracted with ethyl acetate. The extract showed antibacterial and anticancer properties. The extract was processed and the compound isolated was further analyzed using FTIR, mass spectroscopic method and one- and two-dimensional NMR techniques. Based on the data gathered the compound was identified as 7-((5-methylpyridin-2-ylamino) (phenyl) methyl) quinolin-8-ol with a weight-average molecular weight of about 341 Da.

 

Keywords

Streptomyces, HPLC, Mass, NMR, structure elucidation

 

Citation

Sudha Kalyani et al. Bioinformation 19(7): 820-828 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.