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Title

Molecular docking analysis of HSV-1 proteins models with synthetic and plant derived compounds

 

Authors

Ram Krishna1, Mohammad Ajmal Ali2* & Joongku Lee3

 

Affiliation

1ICAR-Indian Institute of Vegetable Research, Varanasi-221005, Uttar Pradesh, India; 2Department of Botany and Microbiology, College of Science, King Saud University,  Riyadh 11451, Saudi Arabia; 3Department of Environment and Forest Resources, Chungnam National University, Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea; *Corresponding authors

 

Affiliation URL:

www.iivr.gov.in

https://faculty.ksu.edu.sa/en/alimohammad

https://plus.cnu.ac.kr/html/en/sub02/sub02_020106.html#link

 

Email

Ram Krishna - E-mail: mbt.r.krishna@gmail.com

Mohammad Ajmal Ali E-mail: alimohammad@ksu.edu.sa:

Joongku Lee E-mail: joongku@cnu.ac.kr

 

Article Type

Research Article

 

Date

Received September 1, 2023; Revised September 30, 2023; Accepted September 30, 2023, Published September 30, 2023

 

Abstract

The atomic resolution model of US9, UL20, and gH protein of HSV is known. Hence, the ligand protein interaction of the US9, UL20, and gH protein models were carried out with synthetic drugs like acyclovir, bexarotene, vinorelbine, foscarnet, famciclovir, cidofovir and two plant derived natural drug acacetin and anthraquinone. Based on structure and docking study, it is predicted that protein US20 and gH binds with particular anti-HSV drug i.e. acyclovir, cidofovir, acacetin and famciclovir, acacetin  respectively, while interaction of different protein is different with drugs.

 

Keywords

HSV, anti-HSV drug, acyclovir, anthraquinone.

 

 

Citation

Krishna et al. Bioinformation 19(9): 981-986 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.