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Linking bone marrow fat with decreased bone mineral density among Indian patients with osteoporotic fracture



Modagan Paranthaman1*, K.S.V. Angu Bala Ganesh2 & Santhi Silambanan3



1*Department of Biochemistry, Dhanalakshmi Srinivasan Medical College and Hospital, Affiliated to The Tamilnadu Dr MGR Medical University, Perambalur 621 113, Tamil Nadu, India; 2Department of Anatomy, Gujarat Adani Institute of Medical Science, Bhuj, Gujarat 370001, India; 3Department of Biochemistry, Sri Ramachandra Medical College, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600 116, Tamil Nadu, India



Modagan Parathaman - E-mail: pmodagan@gmail.com, ORCID: https://orcid.org/0000-0001 -9189-0210.

K.S.V. Angu Bala Ganesh E-mail: ksvangubalaganesh@gmail.com.

Santhi Silambanan - E-mail: santhisilambanan@sriramachandra.edu.in, ORCID: https://orcid.org/0000-0003-0720-6063.


Article Type

Research Article



Received January 1, 2024; Revised January 31, 2024; Accepted January 31, 2024, Published January 31, 2024



Osteoporosis is a systemic skeletal disorder with low-bone mass causing micro-architectural deterioration and an increase in bone fragility and susceptibility to fractures. According to a worldwide report by IOF, 1 in 3 females and 1 in 5 males will experience fractures due to the osteoporotic changes in their bones. Fractures may be the first clinical manifestation of the disease. They have been causes for morbidity and mortality imposing economic burden to osteoporosis. Bone marrow fat is a negative regulator of bone-turnover and a key integrator of bone and energy metabolism. Hence we assess the bone marrow fat and BMD in patients with osteoporotic bone fractures. This cross-sectional study was conducted in 30 patients from the department of orthopaedic surgery. Biopsy samples were received from excised bone during surgery. Biochemical parameters and bone marrow fat were quantified by established methods. A negative correlation between BMD versus serum adiponectin, FGF21 and similar observation with BMD versus bone marrow fat is seen. Therefore, increased bone-marrow fat and adiponectin, FGF21 levels and decreased BMD in osteoporosis. This observation might be useful for prevention, management and therapeutic potential of osteoporosis. Based on our study findings, understand the bone-fat relationship to implications with low BMD in patients with osteoporosis.



Osteoporosis, bone marrow fat, bone mineral density, bone fracture.



Paranthaman et al. Bioinformation 20(1): 49-53 (2024)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.