Title
Biocompatibility and antimicrobial properties of titanium and Zirconium-infused denture base resins
Authors
Rajul Vivek1, Sarita Aneja2, Sneha Amit Rathi3, Abha Kumari*, 4, Harsh Chansoriya5 & Shivakshi Chansoriya6
Affiliation
1Department of Prosthodontics & Crown and Bridge, Purvanchal Institute of Dental Sciences, Gorakhpur, Uttar Pradesh, India; 2Department of Dentistry, Shri Guru Ram Rai Institute of Medical Sciences and Hospital, Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand, India; 3Department of Prosthodontics & Crown and Bridge, Dr HSRSM Dental College, Hingoli, Maharashtra, India; 4Department of Pharmacology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India; 5Department of Prosthodontics & Crown and Bridge, Government College of Dentistry, Indore, Madhya Pradesh, India; 6Department of Oral Medicine and Radiology, Government College of Dentistry, Indore, Madhya Pradesh, India; *Corresponding Author
Rajul Vivek - E - mail: rajul8119@gmail.com; Phone: +91 7376747613
Sarita Aneja - E - mail: drsaritaaneja@gmail.com; Phone: +91 9781813535
Sneha Amit Rathi - E - mail: snehakarwa07@gmail.com; Phone: +91 8007373042
Abha Kumari - E - mail: drabharims@gmail.com; Phone: +91 9431174090
Harsh Chansoriya - E - mail: harsh.chansoria@gmail.com; Phone: +91 9425016952
Shivakshi Chansoriya - E - mail: shivakshi17@gmail.com; Phone: +91 9109996802
Article Type
Research Article
Date
Received October 1, 2024; Revised October 31, 2024; Accepted October 31, 2024, Published October 31, 2024
Abstract
Titanium (Ti) and zirconium (Zr) have gained attention for their promising properties in medical and dental applications, including their biocompatibility and antimicrobial effects. Denture base resins primarily made of polymethyl methacrylate (PMMA), often face issues such as microbial adhesion and limited bioactivity. Incorporating Ti and Zr into these resins could enhance their biological properties. This study investigates the biocompatibility and antimicrobial efficacy of Ti- and Zr-infused denture base resins compared to conventional PMMA resins. Three groups of denture base resins were prepared: Group A (PMMA control), Group B (PMMA + 5 wt% Ti), and Group C (PMMA + 5 wt% Zr). Biocompatibility was assessed by culturing human gingival fibroblasts (HGFs) on resin samples and performing an MTT assay to evaluate cell viability over 72 hours. Antimicrobial properties were tested against Streptococcus mutans and Candida albicans using a colony-forming unit (CFU) assay. Statistical analysis was performed using ANOVA with a significance level of p < 0.05. Group B (Ti-infused) exhibited a 25% increase in cell viability compared to the control group, with cell viability reaching 85% after 72 hours. Group C (Zr-infused) showed a 15% increase in cell viability. Both Ti and Zr groups demonstrated significant antimicrobial activity. Group B showed a 60% reduction in S. mutans CFU and a 45% reduction in C. albicans CFU, while Group C showed a 40% reduction in S. mutans and a 30% reduction in C. albicans. Ti- and Zr- infused denture base resins demonstrate improved biocompatibility and antimicrobial properties compared to conventional PMMA. Titanium, in particular, provides superior biological outcomes, suggesting its potential for enhancing denture base materials. These findings support the incorporation of Ti and Zr in future dental materials to improve patient outcomes.
Keywords
Titanium, zirconium, denture base resins, biocompatibility, antimicrobial properties, polymethyl methacrylate, Streptococcus mutans, Candida albicans.
Citation
Vivek et al. Bioinformation 20(10): 1345-1348 (2024)
Edited by
Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
