Title

Effect of oral alpha lipoic acid in treatment of OSMF

Authors

AK Shafeem Khan^1,*, Vikas Kulkarni¹ & Abhay D. Havle²

Affiliation

¹Department of ENT, Krishna Institute of Medical Sciences, Karad - 415110, Maharashtra, India; ²Department of Otorhinolaryngology, Krishna Institute of Medical Sciences, Karad - 415 539, Maharashtra, India; *Corresponding author

Email

Shafeem Khan A.K - E - mail: shafeemkhan@gmail.com
Vikas Kulkarni - E - mail: vikasent@gmail.com
Abhay D. Havle - E - mail: abhayhavle@yahoo.co.in

Article Type

Research Article

Date

Received October 1, 2024; Revised October 31, 2024; Accepted October 31, 2024, Published October 31, 2024

Abstract

Oral submucous fibrosis (OSMF) is a potentially cancerous disorder that affects the oral mucosa and causes a range of symptoms and limitations in function. Assessing the function of oral alpha lipoic acid (AL-A) as a therapy for OSMF is, therefore, intriguing. Fifty patients with OSMF symptoms were evaluated both before and after treatment. They were split into two groups: group A, which served as the control, received 1 ml SI of thioacetamide (TAA) and 1500 IU of hyaluronidase (HYAL) weekly along with the oral antioxidant α-lipoic acid for three months. Group B, which served as the case study, also received 3 months of SI of TAA and HYAL. Patients in group B were recalled for a clinical examination using a vernier caliper (VC), and visual analog scale (VAS) and fibrous bands (FB) were assessed at the 1st, 3rd, and 6th month. We discovered that controls had a comparable distribution pattern across visits when compared to the case. Treatment with AL-A in conjunction with IL-I of TAA and HYAL significantly reduced the severity of symptoms, especially Burning Sensation (BS) and mouth opening (MO), in the case group over time, as previously determined.

Keywords

Alpha lipoic acid, oral submucous fibrosis, thioacetamide, vernier caliper & hyaluronidase

Citation

Khan et al. Bioinformation 20(10): 1401-1404 (2024)

Edited by

Neelam Goyal & Shruti Dabi

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.