HOME   |    PDF   |   


Adiponectin and HbA1c levels among Indian patients with diabetes mellitus



Mohammad Arif1, Shreya Nigoskar1,* & Manish Kumar Verma2



1Department of Biochemistry, Index Medical College &Research Center Indore, Madhya Pradesh, India; 2Department of Biochemistry, Rajashri Dashrath Autonomous State Medical College Ayodhya, U.P, India; Corresponding author



Mohammad. Arif - E-mail: marif0811@gmail.com

Shreya Nigoskar - E-mail: shreyanigoskar1@gmail.com

Manish Kumar Verma - E-mail: manishverma8919@gmail.com


Article Type

Research Article



Received February 1, 2024; Revised February 29, 2024; Accepted February 29, 2024, Published February 29, 2024



Adiponectin is closely related to glucose metabolism and newly diagnosed type 2 diabetes mellitus (T2DM), and other kinds of diabetes linked to the risk of T2DM. Therefore, it is of interest to report the correlation between adiponectin levels and glycosylated hemoglobin (HbA1c) as a diagnostic marker of T2DM and healthy control. Total 210 participants were included of IPD & OPD healthy controls with glycosylated hemoglobin levels under 6% were included. Blood samples, collected using sterile clot activator or plain vials, were stored at -20°C. The biomarker score that comprised significant differences in age, gender distribution, and metabolic indicators are seen between the diabetes (n=105) and control (n=105) groups. Increase in both Adiponectin and HbA1c% MeanąSD (6.86ą0.23, p<0.0001; 22.71ą2.01; p<0.0001) is indicative of deteriorating glycaemic control and an accompanying rise in inflammatory response. Positively correlate adiponectin levels with HbA1c levels (r2=0.398; p<0.0001), suggesting a link between inflammatory response and glucose control. Lower adiponectin levels are statistically associated with diabetes. Diabetes and adiponectin were negatively correlated and positive linear relationship between HbA1c and adiponectin levels. Adiponectin may be a significant factor useful in understanding the pathophysiology; they are likely to be straight forward instruments for predicting future risk of diabetes.



Adiponectin, Glycosylated Haemoglobin, Type 2 Diabetes Mellitus, Metabolic Disorder, Inflammatory Biomarkers.



Arif et al. Bioinformation 20(2): 202-207 (2024)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.