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Immuno-histochemical evaluation of CD34 for OLP and OSMF



Harshit Shrivastava1, Mahesh Shenoy2, Nishath Sayed Abdul3, Deepashree Pramod Gujjar4, Ajoy Kumar Shahi5, Preeti Dhir6, Bhumika J Patel7 & Ramanpal Singh Makkad8,*



1Department of Oral and Maxillofacial Surgery, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh., India; 2Department of OMFS & Diagnostic Sciences, College of Medicine & Dentistry, Riyadh Elm University, P.O. Box 84891 - Riyadh 11681, Kingdom of Saudi Arabia; 3Faculty of Oral Pathology, Department of OMFS and Diagnostic Sciences, College of Medicine and Dentistry, Riyadh Elm University, Riyadh, Kingdom of Saudi Arabia; 4Department of Oral pathology and Microbiology, Bapuji dental college and hospital, Davanagere-544007, Karnataka, India; 5Department of Oral & Maxillofacial Surgery, Dental Institute, Rajendra institute of Medical Sciences, Ranchi, India; 6Department of Oral Medicine and Radiology, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India; 7Department of Dentistry, Howard University, College of Dentistry, Washington DC, USA; 8Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India;



Harshit Shrivastava - E-mail:drharshit1808@gmail.com

Mahesh Shenoy - E-mail: mahesh.shenoy@riyadh.edu.sa

Nishath Sayed Abdul - E-mail: nishathsayed@riyadh.edu.sa

Deepashree Pramod Gujjar - E-mail:drpramodeepa@gmail.com

Ajoy Kumar Shahi - E-mail:drajoyshahi@gmail.com

Preeti Dhir - E-mail: drpreetikumra@yahoo.in

Bhumika J Patel - E-mail:bhumikapatel2687@gmail.com

Ramanpal Singh Makkad - E-mail: drramanpal@gmail.com


Article Type

Research Article



Received April 1, 2024; Revised April 30, 2024; Accepted April 30, 2024, Published April 30, 2024



Immuno-histochemical evaluation of CD34 in oral lichen planus (OLP) and Oral Submucous Fibrosis (OSMF) is of interest to dentist.20 specimens of normal oral mucosa (buccal mucosa/gingiva tissue) from patients who had extractions performed as part of orthodontic treatment comprised Group I, the control group. Group II comprised 30 individuals with a diagnosis of oral lichen planus. 30 OSMF cases with diagnoses is Group III. These 80 specimens were all given consideration when choosing for CD34immuno-histochemical staining. The CD34 was greater in all categories of OLP and OSMF when compared to normal controls. Maximum CD34 expression was observed in erosive OLP (147.4117.60) followed by OSMF (116.01 11.72) and reticular OLP (105.0111.62). Data was statistically significant (p<0.001).Immunohistochemistry of CD34 evaluation is a potential diagnostic marker for OLP and OSMF.



CD34, immuno-histochemistry, OLP, OSMF



Shrivastava et al. Bioinformation 20(4): 358-361 (2024)


Edited by

Vini Mehta






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.