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Effect of locosamide as an add-on therapy in the management of dissociative disorders



Sambhu Prasad1,*, Anant Kumar Verma2, Santosh Kumar3 & Sweta Gupta4



1Department of Psychiatry, AIIMS, Patna, Bihar, India, 2Department of Psychiatry, Bhagwan Mahavir Institute of Medical Science, Pawapuri, Nalanda, Bihar, India; 3Department of Psychiatry, IGIMS, Patna, Bihar, India; 4Department of Orthodontics and Dentofacial Orthopaedics, Patna Dental College and Hospital, Patna, Bihar, India; *corresponding author



Sambhu Prasad - E-mail: sambhu3011@gmail.com

Anant Verma - E-mail: anantpgi@gmail.com

Santosh Kumar - E-mail: dr.santosh.kr@gmail.com

Sweta Gupta - E-mail: swetabds@gmail.com


Article Type

Research Article



Received April 1, 2024; Revised April 30, 2024; Accepted April 30, 2024, Published April 30, 2024



The role of lacosamide (LCM) as add on treatment modality in dissociative disorders (DD) is of interest. It was a randomized control trial in which 300 patients diagnosed with dissociative disorders having treatment for the dissociative disorders were included. They were divided into two groups. Group one consisted of intervention group in which LCM was also administered along with conventional psychiatric medication for different dissociative disorders. Group two consisted of control group where the patients of dissociative disorders were found to have conventional medication. There was analysis of improvements in recovery of symptoms and quality of life. There was statistically significant increase in excellent, very good, good and fair quality of life and decrease in poor and satisfactory quality of life in intervention group after drug intervention. It was observed that symptoms of the patients improved in 50.67% cases in intervention group and 10.67% cases in control group. There was greater improvement in recovery of symptoms and quality of life in patients of DD in which LCM was administered as add on medication.



Lacosamide, dissociative disorders, randomised control trial



Prasad et al. Bioinformation 20(4): 373-377 (2024)


Edited by

Vini Mehta






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.