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Linking IL-6 and hsCRP among Indian patients with myocardial infarction



Virendra Verma1, Pavan Kumar Sharma2, Shashi Prabha Singh3, Devajit Sarmah4, Rajni Patel5, Poonam Verma6, Shiv Shanker Tripathi7, Deepa Arya2, & Manish Kumar Verma4,*



1Department of Medicine, Rajarshi Dashrath Autonomous State Medical College, Ayodhya, India; 2Department of Biochemistry, Rama Medical College Hospital & Research Centre, Kanpur, India; 3Department of Biochemistry, Maa Vindhyavasini Autonomous State Medical College, Mirzapur, India; 4Department of Biochemistry, Rajarshi Dashrath Autonomous State Medical College, Ayodhya, India; 5Department of Anatomy, Autonomous State Medical College, Etah, India; 6President, Society for Scientific Research, Barabanki, India; 7Department of Emergency Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India; *Corresponding author



Virendra Verma - E-mail: drviru10@gmail.com

Pavan Kumar Sharma - E-mail: doctorpavan1980@gmail.com

Shashi Prabha Singh - E-mail: dr.spsingh084@gmail.com

Devajit Sarmah - E-mail: dr.devajit@gmail.com

Rajni Patel - E-mail: Rajni24rajeev@gmail.com

Poonam Verma - E-mail: poonam.phdbiotech@gmail.com

Shiv Shanker Tripathi - E-mail: shiv_shanker2@rediffmail.com

Deepa Arya - E-mail: Phone: deepaarya27052009@gmail.com

Manish Kumar Verma - E-mail: manishverma8919@gmail.com


Article Type

Research Article



Received April 1, 2024; Revised April 30, 2024; Accepted April 30, 2024, Published April 30, 2024



The association between serum interleukin-6 (IL-6) and highly sensitive C - reactive protein (hsCRP) as predictors of the risk factors for Myocardial Infarction. The study included a total of 50 patients with Myocardial Infarction, aged between 25 to 74 years. The levels of hsCRP were measured using the immunoturbidimetry method, while Interleukin 6 was estimated using the sandwich ELISA method. Statistical analysis was conducted using SPSS version 21.0, with p values calculated using Quartile ratio, ANOVA unpaired t-test, and Kaplan-Meier Curve Method. A p-value of less than 0.05 was considered statistically significant. All participants underwent a questionnaire, physical examination, medical history assessment, and laboratory tests. The results of the study showed that there was a significant correlation between IL-6 and hsCRP levels in the Quartile groups, as well as with lipid profiles. The Kaplan-Meier method also demonstrated a significant association between IL-6 and hsCRP levels in participants. The comparison of biomarkers further supported these findings. Thus, data shows that elevated levels of hsCRP and IL-6 could serve as valuable diagnostic markers for predicting Acute Myocardial Infarction. Our study strongly suggests that IL-6 could be a powerful marker in evaluating the Myocardial Infarction.



Myocardial infarction, Acute Coronary Syndrome, Biochemical Marker, high sensitivity C- reactive protein, Interleukin-6



Verma et al. Bioinformation 20(4): 378-385 (2024)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.