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Detection of corneal pathology among Indians using WBC count as inflammatory marker



Susmitha Joshy1 & MC Chaitra2,*



1Department of Ophthalmology, Sri Devaraj Urs Medical College, Tamaka Kolar, Karnataka, India; 2Department of Ophthalmology, Sri Devaraj Urs Medical College, Tamaka Kolar, Karnataka, India; *Corresponding author



MC Chaitra - E-mail: chaitramc@sduaher.ac.in; drchaitramc@gmail.com; Phone: +91 8197226641

Susmitha Joshy- E-mail: swzkitty@gmail.com


Article Type

Research Article



Received May 1, 2024; Revised May 31, 2024; Accepted May 31, 2024, Published May 31, 2024



The multifaceted role of NLR as a biomarker in corneal pathologies, aiming to enhance clinicians' understanding for better patient outcomes is of interest. An extensive ophthalmic assessment was conducted. Patients with corneal pathologies were identified as cases and those with healthy cornea as controls. A complete WBC blood count was performed using Automated Flow Cytometric method and the counts of white blood cells, neutrophils, platelets, and lymphocytes where recorded. NLR, PLR, and MLR were calculated by dividing the Neutrophil/Platelet/Monocyte counts by the lymphocyte counts. The study revealed that the Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Platelet-to-Lymphocyte Ratio (PLR) were significantly higher in the case group compared to the control group. N/L proved the best predictor among inflammatory markers, followed by M/L and P/L, highlighting the intricate immune response in corneal diseases, urging customized assessments in ocular health research.



WBC, corneal pathology, inflammatory marker



Joshy & Chaitra, Bioinformation 20(5): 478-482 (2024)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.