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Centella asiatica ameliorates AlCl3 and D-galactose induced nephrotoxicity in rats via modulation of oxidative stress



Thirupathirao Vishnumukkala1,2, Prarthana Kalerammana Gopalakrishna3, Barani Karikalan4 Warren Thomas5, Saravanan Jagadeesan6, Samaila Musa Chiroma7, Nurul Huda Mohd Nor1 & Mohamad Aris Mohd Moklas1,*



1Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 2Anatomy discipline, Human Biology Division, School of Medicine, IMU University, Kuala Lumpur, Malaysia; 3Physiology discipline, Human Biology division, School of Medicine, IMU University, Kuala Lumpur, Malaysia; 4Department of Pathology, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Bandar Saujana Putra, Selangor, Malaysia; 5Department of Human Biology, Royal College of Surgeons in Ireland - Medical University of Bahrain, Al Sayh, Muharraq Governate, Kingdom of Bahrain; 6Department of Anatomy, School of Medicine, Taylors University, Lakeside Campus, Selangor, Malaysia; 7Newcastle University Medicine Malaysia, Iskandar Puteri, Johor, Malaysia; *Corresponding author



Thirupathirao Vishnumukkala - E-mail: thirupathirao@imu.edu.my

Prarthana Kalerammana Gopalakrishna - E-mail: prarthana@imu.edu.my

Barani Karikalan - E-mail: barani@mahsa.edu.my

Warren Thomas - E-mail: wathomas@rcsi-mub.com

Saravanan Jagadeesan - E-mail: saravanan.jagadeesan@taylors.edu.my

Samaila Musa Chiroma - E-mail: Musa-Chiroma.Samaila@newcastle.edu.my

Nurul Huda Mohd Nor - E-mail: hudamohdnor@upm.edu.my

Mohamad Aris Mohd Moklas - E-mail: aris@upm.edu.my; Phone No: +603-97692783


Article Type

Research Article



Received May 1, 2024; Revised May 31, 2024; Accepted May 31, 2024, Published May 31, 2024



Nephrotoxicity is a condition caused by toxic effects of medications and poisons resulting in the rapid decline of kidney function. Centella asiatica is a medicinal herb with antioxidative and anti-inflammatory characteristics that is used to treat a variety of ailments. The present study intends to explore the ability of Centella asiatica in preventing AlCl3 and D-Galactose-induced nephrotoxicity in rats. In this study 30 male albino Wistar rats were induced with nephrotoxicity using AlCl3 and D-galactose, and oral administration of Centella asiatica extract (100, 200, and 300mg/kg/day) was administered for 70 days. The kidneys were extracted after treatment and levels of oxidative and antioxidative enzymes, serum creatinine, and serum albumin were measured. The kidney's histopathological changes were studied. Administration of Centella asiatica extract significantly increased serum albumin, superoxide dismutase (SOD), and catalase levels in kidney homogenates while suppressing serum creatinine and malondialdehyde (MDA) levels and attenuating histopathological changes associated with nephrotoxicity. Centella asiatica extract lowered serum creatinine and oxidative stress levels in a drug-induced nephrotoxicity rat model, while simultaneously increasing serum albumin levels, as evidenced by mitigation of histological changes and normalisation of biomarkers of oxidative stress in the kidney.



Centella asiatica, Nephrotoxicity, AlCl3, D-galactose, Oxidative stress



Vishnumukkala et al. Bioinformation 20(5): 508-514 (2024)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.