Title

Linking hypoxia-inducible factor (HIF)-1α and HIF-2α expression in head and neck cancer

Authors

Pratiksha Kumar¹, Megha Prabhakar², Shilpa Motghare³, Arpita Srivastava^4,*, Karandeep Singh⁵, Meena Jain⁶ & Megha Patel⁷

Affiliation

¹Department of Oral Pathology and Microbiology, Government College of Dentistry Indore, Madhya Pradesh, India; ²Department of ENT, SRVS Medical College Shivpuri, Madhya Pradesh, India; ³Department of Pathology, SRVS, Government Medical College, Shivpuri, Madhya Pradesh, India; ⁴Department of Oral Medicine and Radiology, Government College of Dentistry Indore, Madhya Pradesh, India; ⁵Department of Oral & Maxillofacial Surgery, SGT University, Budhera Village, Gurugram, Haryana-122505, India; ⁶Department of Public Health Dentistry, Santosh Dental College, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India; ⁷Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India; *Corresponding author

Email

Pratiksha Kumar - E - mail: dr.pratiksha.kumar@gmail.com
Megha Prabhakar - E - mail: drmegha2009@gmail.com
Shilpa Motghare - E - mail: shilpa.motghare@gmail.com
Arpita Srivastava - E - mail: Khushi5s1@gmail.com
Karandeep Singh - E - mail: karandeepsingh_fdsc@sgtuniversity.org
Meena Jain - E - mail: drmeenabansal@gmail.com
Megha Patel - E - mail: meghapatel@karnavatiuniversity.edu.in

Article Type

Research Article

Date

Received April 1, 2025; Revised April 30, 2025; Accepted April 30, 2025, Published April 30, 2025

Abstract

Hypoxic conditions often occur in solid tumors like those of the head and neck area, thus enhancing tumor evolution while causing both therapeutic resistance and worsening clinical outcomes. Therefore, it is of interest to evaluate the expression of HIF-1α and HIF-2α proteins to correlate with clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Hence, 80 patients with HNSCC participated in this study. The laboratory analysis of tumor tissue, conducted through immunohistochemistry, revealed the expression levels of HIF-1α and HIF-2α. The examined tissues were categorized into low, moderate, and high expression categories based on immunoreactivity scoring. The clinical outcomes of head and neck cancer patients become worse when producers of HIF-1α and HIF-2α elevate in their tumors.

Keywords

Hypoxia-inducible factor, HIF-1α, HIF-2α, head and neck cancer, prognosis, biomarker, immunohistochemistry

Citation

Kumar et al. Bioinformation 21(4): 703-707 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.