Title

Bone regeneration using PRF, PRP and β-TCP in bone defects

Authors

Vipin Arora¹, Ankur Joshi², Nishita Anthwal³, Sameer Gupta⁴, Ashtha Arya^*,5 & Mahima Paul⁶

Affiliation

¹Department of Restorative Dental Sciences, Taif University, Kingdom of Saudi Arabia-21944; ²Department of Dentistry, Government Medical College, Haridwar-249401, Uttarakhand, India; ³Department of Oral Pathology and Microbiology, UDMRI, Dehradun, Uttarakhand-248140, India; ⁴Department of Oral and Maxillofacial Surgery, Inderprastha Dental College and Hospital, Sahibabad, Ghaziabad, Uttar Pradesh - 201010, India; ⁵Deparetment of Conservative Dentistry and Endodontics, SGT Dental College, Hospital and Research Institute, SGT University, Gurugram, Haryana- 122505, India; ⁶Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, KIIT Deemed To Be University, Patia, Bhubaneswar, India; *Corresponding author

Email

Vipin Arora - E - mail: vipinendodontist@gmail.com
Ankur Joshi - E - mail: drankurbjoshi@gmail.com
Nishita Anthwal - E - mail: dr.Nishita11@gmail.com
Sameer Gupta - E - mail: sameer.gupta83@yahoo.in
Ashtha Arya - E - mail: drashthaarya@yahoo.co.in
Mahima Paul - E - mail: mahima.mhs.paul14@gmail.com

Article Type

Research Article

Date

Received April 1, 2025; Revised April 30, 2025; Accepted April 30, 2025, Published April 30, 2025

Abstract

Bone regeneration using platelet-rich fibrin (PRF), platelet-rich plasma (PRP) and beta-tricalcium phosphate (β-TCP) in bone defects is of interest. PRF achieved the maximum bone fill (85%) during the 12 weeks assessment period while PRP and β-TCP reached 75% and 65% bone fill, respectively. Trabecular bone density proved superior in defects treated with PRF according to the histological findings (p < 0.05). The prolonged availability of growth factors from PRF resulted in better bone tissue formation. The biomaterial PRF demonstrates strong potential to become an effective solution for efficient bone healing in clinical medicine.

Keywords

Bone regeneration, platelet-rich fibrin (PRF), platelet-rich plasma (PRP), beta-tricalcium phosphate (β-TCP), bone defects, osteogenesis.

Citation

Arora et al. Bioinformation 21(4): 793-796 (2025)

Edited by

Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.