Title
Effect of radiation exposure on oral mucosal cells: An in vitro study
Authors
Silpi Chatterjee*, 1, Pallavi Choudhary2, Asim Mustafa Khan3, VJ Reshma3, Muhaseena Muhamood3 & Arpita Maitra4
Affiliation
1Department of Public Health Dentistry, Dr. D.Y.Patil Dental College & Hospital, Dr D.Y.Patil Vidyapeeth, Pune, Maharashtra, India; 2Department of Oral and Maxillofacial Surgery, Consultant at Ramakrishna mission hospital and T.B sanatorium, Consultant at K.C Roy memorial hospital and heart centre, Ranchi, Jharkhand, India; 3Department of Biomedical dental sciences, College of dentistry Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 4Department of Oral Medicine and Radiology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India; *Corresponding author
Silpi Chatterjee - E - mail: dr.silpi510@gmail.com
Pallavi Choudhary - E - mail: Pllvchoudhary@gmail.com
Asim Mustafa Khan - E - mail: amkomr@gmail.com
VJ Reshma - E - mail: rvbeevi@iau.edu.sa
Muhaseena Muhamood - E - mail: mmmuhaseena@iau.edu.sa
Arpita Maitra - E - mail: arpita6795@gmail.com
Article Type
Research Article
Date
Received April 1, 2025; Revised April 30, 2025; Accepted April 30, 2025, Published April 30, 2025
Abstract
Radiation generates toxic reactions and DNA damage in oral mucosal cells which depends on the exposure dose during laboratory tests. The survival rate of cells dropped from 98.6% in non-irradiated controls to 40.8% at 8 Gy while both structural cell alterations and DNA damage manifestations became evident. The extent of DNA damage in cells increased as radiation doses became higher according to findings from the Comet assay. Radiation produces marked impact on the defense capacity of oral tissues. Protective measures must be implemented as an essential way to prevent damage to oral mucosa tissues exposed to radiation.
Keywords
Radiation exposure, oral mucosal cells, in vitro study, cytotoxicity, genotoxicity, DNA damage, cell viability, radiation-induced damage.
Citation
Chatterjee et al. Bioinformation 21(4): 823-826 (2025)
Edited by
Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
