Title

Early detection of acute coronary syndrome using traditional versus emerging biochemical markers

Authors

Minakshi Kumari¹, Saket Kumar² & Jhuma Das^1,*

Affiliation

¹Department of Biochemistry, Netaji Subhas Medical College and Hospital, Jamshedpur, Jharkhand, India; ²Department of Pathology, Netaji Subhas Medical College, Jamshedpur, Jharkhand, India; *Corresponding author

Email

Minakshi Kumari - E - mail: dr.minakshijha@gmail.com
Saket Kumar - E - mail: krsaket84@gmail.com

Jhuma Das - E - mail: dasjhuma27@gmail.com

Article Type

Research Article

Date

Received April 1, 2025; Revised April 30, 2025; Accepted April 30, 2025, Published April 30, 2025

Abstract

Early detection of acute coronary syndrome (ACS) becomes more accurate using dependable biomarkers for diagnosis. Therefore, it is of interest to evaluate using established markers (Troponin I, CK-MB) together with emerging markers (H-FABP, Copeptin, IMA) for 150 patients. Analysis of H-FABP yielded the best early sensitivity rate at 92% surpassing both Troponin I and CK-MB values. The combination of H-FABP with Troponin I produced superior ACS detection results (p < 0.05). The use of emerging biomarkers shows better diagnostic precision for standard practice in ACS testing.

Keywords

Acute coronary syndrome, myocardial injury, troponin I, creatine kinase-MB (CK-MB), heart-type fatty acid-binding protein (H-FABP), copeptin, ischemia-modified albumin, early diagnosis

Citation

Kumari et al. Bioinformation 21(4): 870-873 (2025)

Edited by

Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.