Title
Prediction of hyper-bilirubinemia in healthy neonates using umbilical cord blood bilirubin
Authors
Madhav Shridharrao Kadam1, Mohit Garg2, Seema Sutay3, Sandeep Singh Matreja4,*, Priyadarshini Rangari5 & Amit Rangari6
Affiliation
1Department of Biochemistry, Parbhani Medical College and RP Hospital Research Institute, Maharashtra, India; 2Department of General Medicine, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; 3Department of Forensic Medicine and Toxicology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; 4Department of Pathology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; 5Department of Dentistry, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; 6Department of Microbiology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; *Corresponding author
Madhav Shridharrao Kadam - E - mail: kmadhv322@gmail.com
Mohit Garg - E - mail: mohit2503@gmail.com
Seema Sutay - E - mail: seemassutay@gmail.com
Sandeep Singh Matreja - E - mail: dr.sandeepsingh88@gmail.com
Priyadarshini Rangari - E - mail: drpriyakasture@gmail.com
Amit Rangari - E - mail: dr_amit123@gmail.com
Article Type
Research Article
Date
Received May 1, 2025; Revised May 31, 2025; Accepted May 31, 2025, Published May 31, 2025
Abstract
Jaundice is a clinical condition characterized by transient deficiency of bilirubin conjugation, leading to neonatal hyper-bilirubinemia. Therefore, it is of interest to assess cord blood bilirubin at birth as a predictor of neonatal hyper-bilirubinemia needing phototherapy in full-term neonates. In 220 neonates with hyper-bilirubinemia needing phototherapy were assigned as cases and without hyper-bilirubinemia as controls to assess association in serum total bilirubin and cord blood bilirubin were assessed after identifying the cut-off level of cord blood bilirubin. The mean cord blood bilirubin level was 2.64±0.63 and total serum bilirubin estimated on 3rd day of life was 16.14±1.4. 3rd day serum bilirubin and cord blood bilirubin were correlated positively with the (r=0.087). Umbilical cord blood bilirubin estimation is a non-invasive, economical, and simple method of predicting subsequent neonatal hyper-bilirubinemia that can help clinicians for early discharge of normal neonates and follow-up in high-risk infants.
Keywords
Cord blood bilirubin, neonates, neonatal hyper-bilirubinemia, phototherapy, serum total bilirubin
Citation
Kadam et al. Bioinformation 21(5): 906-909 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
